An interventional study of Remote ischemic preconditioning (RIPC) and sham-intervention in Atrial Fibrillation, sponsored by Jedrzej Kosiuk. Status unknown at 1 site in Germany. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-08-22.
Sponsored by Jedrzej Kosiuk · Not applicable, Interventional, and Prevention
The aim of the study is to examine the effect of RIPC on physiological parameters in non-valvular paroxysmal atrial fibrillation. Furthermore the study will provide a unique bio-date base for further analysis of molecular and genetic mechanisms responsible for observed results.
The potential effect of RIPC on AF inducibility and/or prothrombotic activity might be implemented as additional treatment component to reduce AF burden and minimize thromboembolic risk.
Interim Analysis will be done after 73 patients.
3,870 studies on the registry are indexed under Atrial Fibrillation; 924 are open to participants now.
This study's planned enrollment of 146 is close to the median of 144 across 2,380 interventional studies indexed under Atrial Fibrillation.
Browse Atrial Fibrillation studies →This is the only study on the registry with Jedrzej Kosiuk as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
After randomization patients will undergo 3 sessions of RIPC (Remote ischemic preconditioning) intervention: I) on preoperative day, II) 1 h before and III) directly before the blood sample collection and invasive measurement of electrophysiological parameters.
Procedure: Remote ischemic preconditioning (RIPC)
After randomization patients will undergo 3 sessions of sham-intervention: I) on preoperative day, II) 1 h before and III) directly before the blood sample collection and invasive measurement of electrophysiological parameters.
Procedure: sham-intervention
RIPC will be induced by the application of 3 short episodes (5 minutes) of forearm ischemia by cuff sphygmomanometer inflation separated by 5 minutes of reperfusion.
In the control group the cuff will be inflated for 3 times at 10 mm Hg for 5 minutes with 5-minute intervals
inducibility of Atrial Fibrillation by high-rate pacing of 20 s
Time frame: during the Atrial Fibrillation Ablation procedure
sustainability of Atrial Fibrillation measured in seconds
Time frame: during the Atrial Fibrillation Ablation procedure
Plan to share: Undecided
This study is status unknown, as verified in Aug 2017. You cannot join it, but the record below documents what was studied.
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