An observational study in Dental Erosion, sponsored by University of Göttingen. Suspended. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-11-06.
Sponsored by University of Göttingen · Observational
Not only caries but also exposure to acids can lead to loss of tooth structure. This acid-related tooth structure loss is defined as dental erosion.
A relationship between dental erosion and occurence of reflux disease was shown in numerous studies. On the one hand, patients with dental erosions frequently show reflux disease. On the other hand, many - but not all - reflux patients show dental erosions. It is believed that certain salivary parameters might explain, why not all reflux patients alike are affected of dental erosions.
The aim of this study is to analyze the relationship and the extent of occurrence of dental erosions and reflux symptoms, including investigation of certain salivary parameters.
47 studies on the registry are indexed under Tooth Erosion; 7 are open to participants now.
This study's planned enrollment of 30 is below the median of 100 across 13 observational studies indexed under Tooth Erosion.
Browse Tooth Erosion studies →University of Göttingen is the lead sponsor of 37 studies on the registry; 3 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exploratory study
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patients who are treated at the Clinic for Gastroenterology and Gastrointestinal Oncology and have a 24-hours pH monitoring or impedance measurement performed for medical reasons
Other: Collection of saliva samples · Other: Visual detection of BEWE-index
Collection of saliva samples
Visual detection of BEWE-index
Visual assessment of the BEWE-(basic erosive wear examination)-index
Time frame: After removal of the probe (on second day)
Determination of unstimulated and stimulated saliva flow rate (ml/min).
Time frame: While wearing the probe at three time points over 24h: morning, noon, evening
Determination of saliva pH and buffer capacity (mol/L).
Time frame: While wearing the probe at three time points over 24h: morning, noon, evening
Determination of total protein content in saliva (g/L).
Time frame: While wearing the probe at three time points over 24h: morning, noon, evening
Determination inorganic calcium and phosphate in saliva (mmol/L).
Time frame: While wearing the probe at three time points over 24h: morning, noon, evening
Measurement of salivary enzyme activity: Protease, Kollagenase/Gelatinase, Pepsin, Trypsin, and Amylase (U/mL).
Time frame: While wearing the probe at three time points over 24h: morning, noon, evening
No study locations are listed for this record.
Plan to share: No
This study is suspended, as verified in Nov 2020. You cannot join it, but the record below documents what was studied.
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University of Göttingen