CClinicalTrials.gg
Enrolling by invitationNCT02769416NCTTUpdated Jun 16, 2026

The National Center for Testing Treatments in Chronic Spinal Cord and Traumatic Brain Injury

An observational study in Spinal Cord Injury and Traumatic Brain Injury, sponsored by The University of Texas Health Science Center, Houston. Enrolling by invitation at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-06-16.

Sponsored by The University of Texas Health Science Center, Houston · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
5,000
Ages
18 Years and older
Sex
All
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Study summary

The NCTT is a prospective, multicenter, observational research network for subjects with chronic spinal cord and/or chronic traumatic brain injury.

Read the detailed description

Current treatment for Spinal Cord Injury and Traumatic Brain Injury focuses on stabilizing the patient and preventing secondary injury with the aim of maximizing the best chance of recovery. Most patients will show varying amounts of recovery, but, when the injury is severe, that recovery is only partial. Enrollment in the NCTT will allow for classification and characterization of injury, function, co-morbidities, secondary issues/problems, research interests and will serve as a conduit for enrollment into interventional studies.

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Conditions studied

  • Spinal Cord Injury
  • Traumatic Brain Injury

Keywords

  • spinal cord injury
  • traumatic brain injury
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In context

Spinal Cord Injuries

1,948 studies on the registry are indexed under Spinal Cord Injuries; 505 are open to participants now.

This study's planned enrollment of 5,000 is above the median of 60 across 323 observational studies indexed under Spinal Cord Injuries.

Browse Spinal Cord Injuries studies →

Lead sponsor

The University of Texas Health Science Center, Houston is the lead sponsor of 880 studies on the registry; 209 are open to participants now.

Of its 170 completed or terminated interventional studies of FDA-regulated products, 140 (82%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Chronic spinal cord and traumatic brain injury patients, family members, and healthy vounteers

Inclusion criteria

  • History of spinal cord injury and/or brain injury
  • Able to provide HIPAA authorization to share prior medical records/imaging
  • Age 18 and older.

Exclusion criteria

Exclusion Criteria:

  • Life expectancy less than 6 months, vegetative state or co-existing disease or other characteristic that precludes appropriate diagnosis of spinal cord or brain injury.
  • Other condition that, in the opinion of the site investigator, would interfere with adherence to study requirements.
  • Inability or unwillingness of subject or legal guardian/representative to give informed consent (e.g., ward of the state).
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
5,000 participants (estimated)
Target follow-up
5 Years
Patient registry
Yes
Biospecimen retention
Samples with dna

Groups and cohorts

  • Spinal Cord and Traumatic Brain Injury Subjects

    Patients with a history of spinal cord and/or traumatic brain injury will provide data and samples so that they may be queried for interventional studies.

    Other: Data and sample repository

  • Family Members and Healthy Volunteers

    Healthy volunteer controls or family members may be enrolled for identification of genetic mutations.

    Other: Data and sample repository

Interventions

  • OtherData and sample repository

    Subjects with spinal cord and/or traumatic brain injury, family members and healthy volunteers will provide data and samples.

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What researchers measure

Primary outcomes

  1. International Standard Neurological Classification of Spinal Cord Injury

    functional ability (sensory and motor) for spinal cord injury subjects

    Time frame: greater than 6 months post-injury

  2. Disability Rating Scale

    functional outcome scale for brain injury subjects

    Time frame: greater than 6 months post-injury

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Study locations

1 site
  • The University of Texas Health Science Center at Houston
    Houston, Texas 77030, United States
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References and documents

Individual participant data

Plan to share: No — IPD data will not be freely available. Participating centers will share data.

No publications or documents are linked to this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 16, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02769416
Lead sponsor
The University of Texas Health Science Center, Houston
Responsible party
Georgene Hergenroeder (Study Director, PI, Associate Professor, The University of Texas Health Science Center, Houston) — Principal investigator
First posted
May 11, 2016
Start date
Dec 2015
Primary completion
Dec 2035 (estimated)
Completion
Dec 2035 (estimated)
Last update
Jun 16, 2026

Study contacts

Georgene Hergenroeder, PhD
principal investigator · UTHealth

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Interested in this study?

Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.

No contact was published for this record. The registry link below has the sponsor’s details.

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