A Phase 4 interventional study of Dexamethasone and Placebo in Postoperative Cognitive Dysfunction, sponsored by Clinical Hospital Center, Split. Status unknown. Open to participants aged 40 Years to 85 Years. Per ClinicalTrials.gov, last updated 2016-05-10.
Sponsored by Clinical Hospital Center, Split · Phase 4, Interventional, and Prevention
Postoperative cognitive dysfunction (POCD) is the most common complication after cardiac surgery. This prospective study was conducted to investigate the mechanisms of development of POCD following cardiac surgery taking into account surgical technique (with use or no use of extracorporeal circulation). The investigators focused on the role of inflammatory and stress response to surgical procedure as potential factors involved in the pathogenesis of cognitive dysfunction. Systematic inflammatory response in patients undergoing on-pump or off-pump surgery was analyzed by measuring serum levels of C reactive protein (CRP) and occurrence of systemic inflammatory response syndrome (SIRS). Stress response to surgery was evaluated following cortisol levels and its daily variations. The degree of cognitive dysfunction was assessed based on serum levels of S100β. The effect of dexamethasone on the levels of stress and inflammatory response biomarkers, serum levels of S100β, as well as on the development of POCD was compared with control group that received normal saline.
This is a prospective, randomized, double blind, controlled trial. Following detailed past medical history assessment, two days before the surgical procedure neurocognitive function tests, depression and anxiety tests were carried out to assess the participants. Neurocognitive and anxiety tests were repeated on the 6th day after surgical procedure. A battery of tests lasting approximately 40 minutes were administered by a trained neuropsychologist from the Clinical Hospital Center, Split in a standardized fashion, at the same time of the day (10:00 AM) and in the same room at the Cardiac surgery ward. The investigators used a validated battery of tests which enabled the assessment of psychomotor speed, visual-motor coordination, concentration, attention, short-term memory and aspects of executive functioning. The evaluation was based on the following tests: Mini Mental State Examination (MMSE), Wechsler Memory Scale (WMS I \& II), Trail Making Test (TMT A \& B), Symbol Digit Modalities Test (SDMT), Controlled Oral Word Association Test (COWAT) and PsychE computer test. All of the tests except TMT A \& B have alternate forms. Croatian versions of Beck Depression Inventory-Second Edition (BDI II) and State-Trait Anxiety Inventory (STAI-M) were used for preoperative depression and trait and state anxiety assessment, respectively.
One day before the surgery (08:00 AM) blood samples were collected for determination of levels of S100β protein, cortisol and other routine laboratory parameters (white blood cell count (WBC), hematocrit, creatinine, glucose, albumin, sodium, potassium, C reactive protein (CRP), Troponin I hs).
Participants were randomized into two groups to receive either intravenous dexamethasone 0.1 mg/kg or the same volume of normal saline i.v. 10 hours before the surgery. Random sequence generator was used to determine participant allocation.
Anesthesia in all patients was based on fentanyl, midazolam, vecuronium and sevoflurane. The depth of anesthesia was monitored using bispectral index (BIS). During cardiopulmonary bypass alpha-stat technique was used with the maintenance of normothermia (35.5-36.5°C) or spontaneous hypothermia (up to 32°C). With the off-pump technique, the core temperature was maintained between 36 and 37°C. Surgical technique was standardized. Routine hemodynamic monitoring was performed throughout the surgery and continued on the first postoperative day. Plasma levels of S100β protein were determined 6 h and 30 h following the end of on-pump surgery, and 3 h following the end of off-pump surgery. C reactive protein levels and other routine laboratory parameters were measured from blood samples collected 1 h, 4 h and 12 h postoperatively. On the first postoperative day blood samples were collected at 08:00 AM to determine cortisol levels, C reactive protein and other routine laboratory parameters, and cortisol was also measured on the same day at 04:00 PM, and 12:00 AM. C reactive protein and other routine laboratory parameters were repeatedly measured at 08:00 AM on the following postoperative days, except for cortisol levels which were measured on postoperative days 3 and 5. Registered nurse carried out the standardized test (Delirium Observation Screening Scale (DOS) scale) to assess the patients for the development of postoperative delirium from second to fifth postoperative day (at 07:00 AM, 02:00 PM and 10:00 PM).
264 studies on the registry are indexed under Postoperative Cognitive Complications; 54 are open to participants now.
This study's enrollment of 171 is above the median of 110 across 147 interventional studies indexed under Postoperative Cognitive Complications.
Browse Postoperative Cognitive Complications studies →Clinical Hospital Center, Split is the lead sponsor of 5 studies on the registry; 1 is open to participants now.
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Dexamethasone dose of 0.1 mg/kg was administered intravenously 10h before surgery
Drug: Dexamethasone
Equal volume of normal saline (placebo) was administered intravenously 10h before surgery
Other: Placebo
Intravenous dexamethasone (0.1 mg/kg) was administered 10 hours before surgery.
Also known as: Dexasone
Normal saline (placebo) in the equal volume as active treatment was administered 10 hours before surgery.
Also known as: Inactive substance
Difference in occurrence of postoperative cognitive dysfunction between control and intervention group at six days after surgery as determined by using a validated battery of cognitive tests
Difference in occurrence of postoperative cognitive dysfunction between control and intervention group at sixth postoperative day as determined by using a validated battery of cognitive tests that assess global cognitive function, psychomotor speed, visual-motor coordination, concentration, attention, short-term memory, learning curve and aspects of executive functioning. Time points of assessment are two days before surgery and six days after surgery in both study arms.
Time frame: 9 days
Change in serum levels of S100β protein from baseline to first postoperative day
Serum levels of S100β protein were determined the day before surgery at 08:00 AM; 6 h and 30 h following the end of on-pump surgery; and 3 h following the end of off-pump surgery.
Time frame: 3 days
Difference in S100β serum protein levels between control and intervention group on the day of surgery and first postoperative day
Time frame: 7 days
Change in serum cortisol levels from baseline to fifth postoperative day
Cortisol levels were determined on the day before surgery at 08:00 AM; on the first postoperative day at 08:00 AM, 04:00 PM, and 12:00 AM; and at 08:00 AM on the third and fifth postoperative days.
Time frame: 7 days
Difference in serum cortisol levels between control and intervention group on the first, third and fifth postoperative days
Time frame: 7 days
Change in serum C reactive protein levels from baseline to fifth postoperative day
Baseline CRP levels were determined on the day before surgery at 08:00 AM, 1 h, 4 h and 12 h postoperatively; and at 08:00 AM from the first until fifth postoperative day.
Time frame: 7 days
Difference in serum C reactive protein levels between control and intervention group on the day of surgery until the fifth postoperative day
Time frame: 7 days
Difference in occurrence of systemic inflammatory response syndrome between control and intervention group within 48 h after surgery as determined by measuring body temperature, heart rate, respiratory rate, and white blood cell count.
Time frame: 48 hours
Difference in occurrence of postoperative delirium between control and intervention group as determined from second until sixth postoperative day by using Delirium Observation Screening Scale
Time frame: 5 days
No study locations are listed for this record.
Plan to share: No
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Postoperative Cognitive Complications→
Clinical Hospital Center, Split