An observational study in Surgery and Acute Phase Reaction, sponsored by Karolinska University Hospital. Completed at 2 sites in Sweden. Open to male participants aged 50 Years to 85 Years. Per ClinicalTrials.gov, last updated 2019-04-16.
Sponsored by Karolinska University Hospital · Observational
The primary hypothesis that orthopaedic surgery induces a neuroinflammatory response within 48 hours after elective hip or knee surgery and that there is an association between exaggerated CNS inflammatory response or impaired inflammatory resolution and postoperative cognitive dysfunction within one week and at three months postoperatively.
Patients at 50-85 years of age undergoing orthopedic surgery will be investigated in the perioperative period to detect signs of neuroinflammation using serial CSF and blood sampling for 48 hours in combination with cognitive testing preoperatively, at 3-7 days and after 3 months.
150 studies on the registry are indexed under Neuroinflammatory Diseases; 70 are open to participants now.
This study's enrollment of 34 is below the median of 100 across 52 observational studies indexed under Neuroinflammatory Diseases.
Browse Neuroinflammatory Diseases studies →Karolinska University Hospital is the lead sponsor of 275 studies on the registry; 54 are open to participants now.
Counted across the registry records on this site, refreshed daily.
34 elective orthopedic patients undergoing hip or knee arthroplasty
Exclusion Criteria:
Neuroinflammation measured as IL-6 in CSF
IL-6 in CSF
Time frame: Up to 48 hours postoperatively
Cognitive function
A cognitive test battery will be applied
Time frame: Before surgery, within 7 days after surgery and 3 month after surgery
Peripheral inflammatory response
Cytokines i peripheral blood
Time frame: Up to 48 hours
Neuroinflammation
CNS specific markers in blood
Time frame: Up to 48 hours
Neuroinflammation
CNS specific markers in CSF
Time frame: Up to 48 hours postoperatively
Neuroinflammation
INflammatory Inflammatory markers in CSF
Time frame: Up to 48 hours postoperatively
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Apr 2019. You cannot join it, but the record below documents what was studied.
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Karolinska University Hospital