An observational study in Ischemic Stroke, Carotid Artery Disease and Embolic Stroke, sponsored by Haukeland University Hospital. Completed at 1 site in Norway. Open to participants aged 15 Years and older. Per ClinicalTrials.gov, last updated 2021-02-15.
Sponsored by Haukeland University Hospital · Observational
BACKGROUND: In 30-40% the cause of ischemic stroke remains undetermined. Most likely, this category hides an additional number of strokes caused by artery-to-artery embolisms due to unidentified atherosclerotic disease, or caused by cardioembolism. Both types are associated with a high risk of recurrent ischemic events and multiple cerebral infarctions.
Large-artery atherosclerosis of the brain-supplying arteries is the assumed underlying cause in 10 to 15% of ischemic stroke, mostly deriving from the extracranial carotid artery. Carotid intima-media thickness (cIMT) measured by 2-dimensional (2D) B-mode ultrasonography and estimation of the overall atherosclerotic plaque burden aids future risk prediction. Arterial wall changes, artery caliber variations, degree of stenosis, local hemodynamic alterations and certain plaque characteristics are important for the evaluation of plaque vulnerability and vascular risk stratification. Transcranial Doppler monitoring (TCDM) is a non-invasive bedside examination eligible for detection of microemboli in the human cerebral circulation.
HYPOTHESIS: Atherosclerotic stenosis and plaque characteristics can be more accurately assessed by the combination of routine 2D ultrasound, contrast enhanced ultrasound (CEUS), and 3-dimensional (3D) ultrasound. TCDM, CEUS and 3D visualization of the carotid plaque improve the differentiation of stroke etiology and quantification of plaque vulnerability, and aid the prediction of future risk for cerebrovascular events in the individual patient.
AIMS: Assessment of prevalence and frequency of Microemboli signals (MES) in unselected patients with cerebral ischemia, the influence of antithrombotic drugs on MES, and the relationship between MES and recurrent stroke or Transient ischemic attack (TIA).
Categorization of atherosclerotic carotid artery disease by use of routine and advanced neurosonographic techniques combined with anamnestic and clinical data.
Development of a visualization solution tailored for 3D visualization of carotid arteries and semi-automatic plaque segmentation.
40 studies on the registry are indexed under Embolic Stroke; 11 are open to participants now.
This study's enrollment of 16 is below the median of 364 across 27 observational studies indexed under Embolic Stroke.
Browse Embolic Stroke studies →Haukeland University Hospital is the lead sponsor of 284 studies on the registry; 59 are open to participants now.
Compared within Embolic Stroke, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Ischemic Stroke. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Patients with symptomatic and asymptomatic carotid artery disease admitted to the Dept. of Neurology at Haukeland University Hospital, Bergen/ Norway
Inclusion Criteria:
Symptomatic carotid artery disease
Asymptomatic carotid artery disease
Ischemic stroke or TIA documented by Medical record
Time frame: 3 months
Any arterial event documented by Medical record (composite)
Ischemic stroke, TIA, Coronary artery disease, Myocardial infarction, Peripheral arterial disease
Time frame: 3 months
This study is completed, as verified in Aug 2016. You cannot join it, but the record below documents what was studied.
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