TerminatedNCT02757677Updated May 10, 2022

Evaluation of Blood Flow Characteristics in Glaucoma Using Optical Coherence Tomography Angiography (OCT-A).

An observational study in Glaucoma, sponsored by Swiss Vision Network. Terminated at 1 site in Switzerland. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-05-10.

Sponsored by Swiss Vision Network · Observational

Why this study was terminated

Difficulties with recruitment

Study type: Observational
Model: Cohort
Time perspective: Prospective
Enrollment: 200
Ages: 18 Years and older
Sex: All

Study summary

The investigators aim to evaluate the efficacy of the new Optical Coherence Tomography based Angiography (OCT-A) softwares in the diagnosis and management of glaucoma.

Conditions studied

Glaucoma

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Glaucoma 1,818

In context

Glaucoma

1,818 studies on the registry are indexed under Glaucoma; 231 are open to participants now.

This study's enrollment of 200 is above the median of 103 across 454 observational studies indexed under Glaucoma.

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Lead sponsor

Swiss Vision Network is the lead sponsor of 3 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 18 Years and older
Sexes eligible: All
Accepts healthy volunteers: No
Sampling method: Non-probability sample

Study population

All patients will be enrolled from glaucoma clinics of the Montchoisi glaucoma center.

Inclusion criteria

Diagnosis of open angle glaucoma (OAG) including pseudo-exfoliative and pigmentary glaucoma.
Documented glaucomatous visual field damage (in the previous 12 months with mean defect (MD) > 2.0 dB)
Structural and/or functional glaucomatous damage
Have given written informed consent, prior to any investigational procedures

Exclusion criteria

Exclusion Criteria:

Patients with allergy to corneal anesthetic
Patients not able to understand the character and individual consequences of the investigation
Participation in other clinical research within the last 4 weeks
Other diseases that may cause visual field loss or optic disc abnormalities
Refractive error of > +3.00D or \< -7.00D

Study design

Observational model: Cohort
Time perspective: Prospective
Enrollment: 200 participants (actual)
Patient registry: No

Groups and cohorts

Longitudinal arm
Evaluate optic nerve head blood flow using the new OCT-A software in surgically and medically treated glaucoma patients and in different types of glaucoma
Device: Optical Coherence Tomography based Angiography
24-h Intraocular pressure (IOP) arm
Evaluate the correlation between circadian IOP changes and optic nerve head blood flow using the new OCT-A software
Device: Optical Coherence Tomography based Angiography
Surgery arm
Evaluate blood flow using the new OCT-A software in surgically treated glaucoma patients
Device: Optical Coherence Tomography based Angiography

Interventions

DeviceOptical Coherence Tomography based Angiography
A contrast-free, noninvasive technology to identify blood vessels in the eye

What researchers measure

Primary outcomes

Macular and optic nerve head bloodflow, as measured by OCT-A macular and optic nerve head vessel density (%)
Time frame: Up to 3 years

Study locations

1 site

Glaucoma center, Montchoisi clinic
Lausanne, 1006, Switzerland

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on May 10, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT02757677
Lead sponsor: Swiss Vision Network
Responsible party: Dr. Kaweh Mansouri (dr. Kaweh Mansouri, Swiss Vision Network) — Principal investigator
First posted: May 2, 2016
Start date: Dec 31, 2015
Primary completion: Dec 31, 2019
Completion: Dec 31, 2019
Last update: May 10, 2022

Study contacts

Kaweh Mansouri, MD

principal investigator · Glaucoma center, Montchoisi clinic, Swiss vision network

Oversight

Data monitoring committee: No

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is terminated, as verified in May 2022. You cannot join it, but the record below documents what was studied.

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Discussion

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