An interventional study of Antioxidant (l-cratinine) + modifiable lifestyle factors in Oligoasthenoteratozoospermia, sponsored by Benha University. Status unknown at 3 sites in Egypt. Open to female participants aged 20 Years to 39 Years. Per ClinicalTrials.gov, last updated 2016-11-28.
Sponsored by Benha University · Not applicable, Interventional, and Treatment
This study is the first to evaluate the effect of oral supplementation with antioxidants combined with lifestyle modification for severe male factor partner of couples undergoing ICSI.
Patients underwent a therapy of a three-month period of treatment with either oral L-carnitine only (2g daily) or oral carnitine (2g daily) combined with modifiable lifestyle factors.
64 studies on the registry are indexed under Oligospermia; 17 are open to participants now.
This study's planned enrollment of 60 is close to the median of 65 across 46 interventional studies indexed under Oligospermia.
Browse Oligospermia studies →Benha University is the lead sponsor of 362 studies on the registry; 66 are open to participants now.
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Exclusion Criteria:
In the control group, all patients will go a double-blind therapy of a three-months period of treatment with oral carnitine (2g daily). After this period, all patients will undergo conventional intacytoplasmic sperm injection (ICSI).
In the study group, all patients underwent a double-blind therapy of a six-month period of treatment with oral carnitine (2g daily) combined with modifiable lifestyle factors. Patients were requested to follow a healthy standard diet, avoid excessive heat exposure, avoid or minimize exposure to pollutants, and stop smoking, coffee, alcohol, and drugs uptake.After this period, all patients will undergo conventional ICSI.
Other: Antioxidant (l-cratinine) + modifiable lifestyle factors
All participants were subjected to the same three-month period treatment protocol, which included 1) antioxidant treatment with L-Carnitine (2g daily); 2) frequent ejaculation every 2 days; and 3) minimizing adverse lifestyle factors.
Clinical pregnancy rate
Time frame: two weeks
Implantation rate
Time frame: one month
Plan to share: Yes — Publishing a manuscript
The record gives a start of Apr 2016 and a primary completion of Dec 2016. It does not say whether these dates are actual or estimated.
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This study is status unknown, as verified in Nov 2016. You cannot join it, but the record below documents what was studied.
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