A Phase 4 interventional study of Isobaric marcaine and Hyperbaric marcaine in Cardiac Output, Hypotension and Anesthesia, Spinal, sponsored by Mahidol University. Completed at 1 site in Thailand. Open to female participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-07-31.
Sponsored by Mahidol University · Phase 4, Interventional, and Treatment
Spinal block leads to the reduction of systemic vascular resistance (SVR) which may effect the cardiac output. Ngan Kee et al. has showed that spina block with 0.5% hyperbaric bupivacaine for Cesarean section combined with intravenous infusion norepinephrine had higher cardiac output than those who received phenylephrine
1,003 studies on the registry are indexed under Hypotension; 173 are open to participants now.
This study's enrollment of 168 is above the median of 80 across 675 interventional studies indexed under Hypotension.
Browse Hypotension studies →Mahidol University is the lead sponsor of 730 studies on the registry; 118 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Isobaric Marcaine 2.2 mL for spinal block
Drug: Isobaric marcaine
Hyperbaric Marcaine 2.2 mL for spinal block
Drug: Hyperbaric marcaine
Isobaric marcaine 2.2 mL for spinal block
Also known as: bupivacaine
Hyperbaric marcaine 2.2 mL for spinal block
Also known as: bupivacaine
Change of cardiac output (L/min) after spinal block
The investigators will measure cardiac output using non-invasive methods (USCOM) before spinal block and 5 minutes after spinal block.
Time frame: 5 minutes after spinal block
Total dose of vasopressor
The investigators will record the total dose that treat hypotension during preoperative period
Time frame: 2 hours
Number of patients who experience systolic blood pressure < 25% of preoperative measurement
The investigators will monitor blood pressure at interval; before spinal block, then after spinal block every 1 minute for 10 for 10 times, every 2 minute for 5 times, every 3 minutes until delivery then every 5 minutes til the end of surgery. If the patient's systolic blood pressure is declined, vasopressor will be given.
Time frame: 2 hours
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Jul 2017. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Mahidol University