An interventional study of 20 meters air dive in Decompression Sickness, sponsored by University Hospital, Brest. Completed at 1 site in France. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-06-14.
Sponsored by University Hospital, Brest · Not applicable, Interventional, and Basic science
Diving disorders and particularly Decompression sickness (DCS) represent a major concern in recreational and occupational pressure-related activities. As a result of decompression from higher to lower ambient pressure bubbles which are formed in vascular flow and in tissues take part in embolism then resulting in DCS. Individual factors such as vascular or respiratory defects are now considered to increase the risk of this dysbarism disease.
2 groups of occupational divers will be separated after a fitness medical examination by regarding DLCO decrease or not.
The divers will be evaluated before and 30, 60, 180 minutes after a 20 meters air dive. Venous bubbles will be detected by precordial Doppler 30 minutes after the dive.
In association with this Doppler, Flow Mediated Dilation, blood samples analysing inflammatory and thrombotic factors and other biomarkers will be explored before and after the dive in order to know how vascular and respiratory tracts in this environment react.
21 studies on the registry are indexed under Decompression Sickness; 6 are open to participants now.
Browse Decompression Sickness studies →University Hospital, Brest is the lead sponsor of 601 studies on the registry; 136 are open to participants now.
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Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
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Other: 20 meters air dive
A dive in the depth of 20 m during 40 minutes. The divers will be evaluated before and 30, 60, 180 minutes after a 20 meters air dive. Venous bubbles will be detected by precordial Doppler 30 minutes after the dive. In association with this Doppler, Flow Mediated Dilation, blood samples analysing inflammatory and thrombotic factors and other biomarkers will be explored before and after the dive in order to know how vascular and respiratory tracts in this environment react.
Venous bubbles will be detected by precordial Doppler
Venous bubbles will be detected by precordial Doppler
Time frame: 30 minutes after the dive
Vascular abnormality
Assessement of microvascular reactivity by brachial artery flow mediated dilation
Time frame: 60 minutes after the dive
Coagulation activation
Assessment of blood coagulation factor after the dive
Time frame: 60 minutes after the dive
Inflammatory activation
Assessment of inflammatory factor after the dive
Time frame: 60 minutes after the dive
Ran from Mar 2016 to primary completion in May 2017, 14 months.
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This study is completed, as verified in Jun 2017. You cannot join it, but the record below documents what was studied.
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