An observational study in Atrial Fibrillation, sponsored by Klinik für Kardiologie, Pneumologie und Angiologie. Completed at 1 site in Germany. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2017-11-14.
Sponsored by Klinik für Kardiologie, Pneumologie und Angiologie · Observational
Pulmonary vein isolation (PVI) has become a standard therapy for atrial fibrillation (AF), however, there is still considerable AF recurrence after PVI. Except for PV-left atrium (LA) reconnection, the cause of recurrence has been not yet fully clarified.
The alternation of autonomic tone plays an important role in initiation of paroxysmal AF. It was reported that there are multiple gangliated plexus (GP) around pulmonary veins, therefore the modulation targeting those GPs, resulting in modulations of cardiac autonomic tone, have been conducted. Some study showed the efficacy of GP ablation for AF patients.
According to the previous reports, heart rate (HR) increased, and heart rate variability (HRV) reduced after PVI. These are considered to be due to "autonomic denervation" caused by catheter ablation of GP.
For the best of investigators knowledge, there have been no data on heart rate turbulence (HRT) of baroreflex sensitivity (BRS) concerning PVI.
3,870 studies on the registry are indexed under Atrial Fibrillation; 923 are open to participants now.
This study's enrollment of 50 is below the median of 300 across 1,362 observational studies indexed under Atrial Fibrillation.
Browse Atrial Fibrillation studies →Klinik für Kardiologie, Pneumologie und Angiologie is the lead sponsor of 17 studies on the registry; 4 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients who undergo PVI for paroxysmal AF
Exclusion Criteria:
recurrence of AF
Time measured in days to recurrence of AF
Time frame: 12 months
effect of PVI on cardiac autonomic system utilizing HRT measurement
Time frame: 12 months
effect of PVI on cardiac autonomic system utilizing BRS measurement
Time frame: 12 months
association between measured parameters (HRT, BRS) and the recurrence of AF
Time frame: 12 months
This study is completed, as verified in Nov 2017. You cannot join it, but the record below documents what was studied.
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Klinik für Kardiologie, Pneumologie und Angiologie