An interventional study of Nicotinamide Riboside and Matching placebo in Concussion, Mild, sponsored by Mayo Clinic. Completed at 2 sites in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-08-03.
Sponsored by Mayo Clinic · Not applicable, Interventional, and Screening
Can nicotinamide riboside (750 mg/day for 12 weeks) affect the levels of NAD+ in the brain as measured by 31P MRS?
Healthy collegiate athletes (football, soccer, rugby, hockey, and volleyball) will take Nicotinamide Riboside (NR) or placebo twice daily for 84 days. Pre- and post-intervention evaluations include physical assessment, blood tests for safety and toxicity monitoring, blood tests for biomarkers, neurologic testing, quality of life questionnaires, and the 31P MRI exam.
550 studies on the registry are indexed under Brain Concussion; 154 are open to participants now.
This study's enrollment of 30 is below the median of 64 across 376 interventional studies indexed under Brain Concussion.
Browse Brain Concussion studies →Mayo Clinic is the lead sponsor of 3,263 studies on the registry; 670 are open to participants now.
Of its 450 completed or terminated interventional studies of FDA-regulated products, 318 (71%) have results posted.
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Exclusion Criteria:
Healthy collegiate athletes will take active Nicotinamide Riboside
Dietary Supplement: Nicotinamide Riboside
Healthy collegiate athletes will take a matching placebo
Other: Matching placebo
Three capsules, twice per day for 84 days
Also known as: Niagen
Three matching capsules, twice per day for 84 days
Change in brain NAD+ levels
As measured by 31P MRI
Time frame: baseline, day 84
Plan to share: Yes
This study is completed, as verified in Aug 2022. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Nicotinamide-beta-riboside