An interventional study of AMT in Keratitis of Both Eyes, sponsored by Farabi Eye Hospital. Status unknown. Per ClinicalTrials.gov, last updated 2016-03-29.
Sponsored by Farabi Eye Hospital · Not applicable, Interventional, and Treatment
In this study Investigators are going to do early amniotic membrane transplantation (AMT) for bacterial keratitis.
In this study investigators are going to do amniotic membrane transplantation (AMT), early in the first week for bacterial keratitis. Investigators are comparing this technique with no amniotic membrane transplantation (NAMT) in a clinical trial, Inform consent is going to be taken, then the enrolment population is added in the study. Investigators are going to compare the final scar size, the time to scar formation, perforation rate , early need to penetrating keratoplasty (PKP), risk of vision loss (being no light perception (NLP) between two groups.This trial has been approved by the review board in Tehran University of Medical Sciences.( 487/5671)
126 studies on the registry are indexed under Keratitis; 15 are open to participants now.
This study's planned enrollment of 14 is below the median of 36 across 79 interventional studies indexed under Keratitis.
Browse Keratitis studies →Farabi Eye Hospital is the lead sponsor of 4 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Bacterial keratitis being in the first week of diagnosis medically undergoing treatment
Exclusion Criteria:
thinning limbal extension intraocular extension underlying disease Nocardia keratitis
Freshly prepared fortified eye drops (cefazolin 50 mg/mL and amikacin 14 mg/mL) were applied as starting treatment. In the first 3 days, eye drops are applied round the clock followed by drops every 2 h during waking hours until results of laboratory investigation were available. After preparation of the culture results, the antimicrobial treatment was narrowed according to bacterial sensitivity. Also topical betamethasone 0.1% four times a day on a tapering weekly dosage until 3-4 weeks is used for all patients. If the patient underwent any tectonic procedure during the treatment such as keratoplasty, cyanoacrylate glue are documented
This group (case group) received above mentioned routine antibiotic therapy followed by double-layer amniotic membrane transplantation 2-5 days after the start of medications and the second group (control group) only received routine antibacterial therapy. The AM was trimmed in two layers to fit the corneal ulcer and was placed with its epithelium (basement membrane) side up, secured with 10/0 nylon sutures, supported by a therapeutic contact lens. If the patient underwent any tectonic procedure during the treatment such as keratoplasty, cyanoacrylate glue are documented.
Procedure: AMT
The AM was trimmed in two layers to fit the corneal ulcer and was placed with its epithelium (basement membrane) side up, secured with 10/0 nylon sutures, supported by a therapeutic contact lens. The operated eye was patched for 2 h, and then administration of the medical treatment agents was resumed. In patients in the case group AMT was performed during days 2-5 of antibiotic therapy when initial clinical response to the treatment was observed.
Time to scar formation
The time keratitis needs for scar to be formed
Time frame: It needs at most 3 months
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
This study is status unknown, as verified in Mar 2016. You cannot join it, but the record below documents what was studied.
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Farabi Eye Hospital