An interventional study of Mixed Meal Challenge and Glucose Challenge in Insulin Resistance, sponsored by Menzies Institute for Medical Research. Status unknown at 2 sites in Australia. Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-04-06.
Sponsored by Menzies Institute for Medical Research · Not applicable, Interventional, and Screening
Insulin resistance (or pre-diabetes) is diagnosed using the oral glucose tolerance test. However, high blood glucose levels during this test may adversely impact on microvascular function. Investigators will determine whether a liquid mixed meal challenge (from carbohydrate, protein and fat) is a more appropriate test for assessing microvascular-derived insulin resistance.
After consuming a meal, 80% of glucose is disposed in skeletal muscle. Our research group has demonstrated that microvascular blood flow in skeletal muscle plays an integral role in this process. Physiological doses of insulin stimulate microvascular blood flow, and that this increase is associated with enhanced glucose uptake by muscle. This microvascular action of insulin is lost during insulin resistance and type 2 diabetes.
The oral glucose tolerance test (GTT) is the gold standard for assessing insulin resistance and pre-diabetes and is used world-wide. However high blood glucose levels following a glucose load may adversely impact on microvascular function. The aim of this project is to determine whether a mixed meal challenge (liquid drink consisting of carbohydrate, fat and protein) is a better test for assessing microvascular-derived insulin resistance.
2,025 studies on the registry are indexed under Insulin Resistance; 308 are open to participants now.
This study's planned enrollment of 45 is above the median of 40 across 1,587 interventional studies indexed under Insulin Resistance.
Browse Insulin Resistance studies →Menzies Institute for Medical Research is the lead sponsor of 9 studies on the registry; 2 are open to participants now.
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Exclusion Criteria:
Participants will consume a liquid mixed meal (\~300 calories - fat, carbohydrate, and protein) for monitoring changes in glucose metabolism, plasma insulin and microvascular responses in skeletal muscle over 2 hours.
Other: Mixed Meal Challenge
Participants will consume a glucose challenge (50g glucose) for monitoring changes in glucose metabolism, plasma insulin and microvascular responses in skeletal muscle over 2 hours.
Other: Glucose Challenge
Liquid mixed meal (300 calories - fat, carbohydrate, and protein).
Glucose drink (50g glucose)
Change from baseline in muscle microvascular blood flow
Microvascular responses will be measured by contrast enhanced ultrasound before and 1hr after each challenge.
Time frame: 1 hr
Changes in blood glucose levels
Blood glucose levels will be measured at 0, 15, 30, 60, 90 and 120 min following each challenge.
Time frame: 2 hr
Changes in plasma insulin levels
Plasma insulin levels will be measured at 0, 15, 30, 60, 90 and 120 min following each challenge.
Time frame: 2hr
Changes in the respiratory exchange ratio (RER)
Changes in RER will be measured by metabolic cart during each challenge.
Time frame: 1 hr
Plan to share: No
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This study is status unknown, as verified in Apr 2021. You cannot join it, but the record below documents what was studied.
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Menzies Institute for Medical Research