An interventional study of Local cerebral oxygen saturation in Septic Shock, sponsored by Southeast University, China. Status unknown. Open to participants aged 19 Years to 85 Years. Per ClinicalTrials.gov, last updated 2016-03-11.
Sponsored by Southeast University, China · Not applicable, Interventional, and Treatment
Early goal directed therapy (EGDT) is an effective treatment for patients with septic shock, which is widely used in clinic. Fluid resuscitation can significantly reduce the mortality of patients with septic shock and improve the prognosis of patients with EGDT. However, in recent years, the standard of EGDT to determine the existence of the target of septic shock. Some studies have shown that there may be a manifestation of the deficiency of kidney and liver and other organs such as kidney, liver and other organs in the recovery of EGDT. Therefore, this experiment is to explore the brain perfusion and metabolism of the EGDT when the target is reached.The aim of this study was to investigate the effects of EGDT as a guide to the cerebral perfusion and metabolism in order to provide clinical evidence for the treatment of fluid resuscitation in patients with septic shock.
862 studies on the registry are indexed under Shock, Septic; 207 are open to participants now.
This study's planned enrollment of 26 is below the median of 80 across 530 interventional studies indexed under Shock, Septic.
Browse Shock, Septic studies →Southeast University, China is the lead sponsor of 164 studies on the registry; 44 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Liquid recovery is not fully achieved EGDT standards, at least meet the following criteria:
Exclusion Criteria:
use NIRS technical to detect local cerebral oxygen saturation of both sides of brain
Other: Local cerebral oxygen saturation
take blood culture before antibiotic use;measure the blood lactate;liquid rescisutation as 20ml/kg
change of local cerebral oxygen saturation between early goal directed treatment(EGDT)
Test the local cerebral oxygen saturation of both sides of brain through near infrared spectroscopy technology. And record the change of local cerebral oxygen of the left and right's brain.
Time frame: through study completion, up to 6 hours
change of neuron specific enolase(NSE)
NSE is an enzyme that in humans is encoded by the ENO2 gene. NSE is produced by small cell carcinomas which are neuroendocrine in origin, and the raise of its concentration indicates the injury of brain.
Time frame: through study completion, up to 6 hours
change of S-100 protein
S-100 protein S100 proteins are normally present in cells derived from the neural crest (Schwann cells, and melanocytes), chondrocytes, adipocytes, myoepithelial cells, macrophages, Langerhans cells, dendritic cells, and keratinocytes.S100 proteins have been implicated in a variety of intracellular and extracellular functions.
Time frame: through study completion, up to 6 hours
No study locations are listed for this record.
Plan to share: No — The data is personal, and will not share to others.
No publications or documents are linked to this record.
This study is status unknown, as verified in Feb 2016. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Southeast University, China