A Phase 3 interventional study of sublingual misoprostol and vaginal misoprostol in Missed Abortion, sponsored by Ain Shams University. Completed at 1 site in Egypt. Open to female participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2017-08-16.
Sponsored by Ain Shams University · Phase 3, Interventional, and Treatment
Among 12 studies in Abortion, Missed with a site in Egypt — none open to participants now, none under way, none of them phase 3. Abortion, Missed · Egypt.
Among the 12 studies in Abortion, Missed with a site in Egypt, this one is the 4th largest by enrollment of the 11 interventional ones, is the only one that started in 2016, is one of 2 in phase 3, and was the 2nd registered.
48 studies on the registry are indexed under Abortion, Missed; 10 are open to participants now.
This study's enrollment of 200 is above the median of 110 across 41 interventional studies indexed under Abortion, Missed.
Browse Abortion, Missed studies →None of the 12 studies in Abortion, Missed with a site in Egypt is open now.
Of the 5 Abortion, Missed studies recruiting now, 0 (0%) set no upper age limit and 5 (100%) stop at 75 or younger; 0 take children under 18; 1 take healthy volunteers.
This study: 18 Years to 40 Years · female · no healthy volunteers.
The full table on the hub →12 studies; the count open now beside each. This study's row is marked.
First in 2015; this study’s year is marked. 1 started in 2016.
Median enrollment 140 across the 11 interventional studies, 320 across the 1 observational. Of the 5 that completed or were terminated, 0 (0%) have results posted.
None of the 12 has an industry lead sponsor. The 7 most frequent:
Ain Shams University is the lead sponsor of 1,950 studies on the registry; 429 are open to participants now.
Of its 35 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Ain Shams University has 2 studies filed under Abortion, Missed — fewer than ten, so there is no comparison to draw.
None of the studies under way reaches primary completion within a year.
Among the 12 studies in Abortion, Missed with a site in Egypt, from their registry updates:
Nothing recorded among them since 2026-09-25.
The aim of this work is to compare the effectiveness of vaginal versus sub-lingual misoprostol for medical treatment of first trimester missed miscarriage.
In women with first trimetric-missed miscarriage, sublingual misoprostol may be as vaginal misoprostol in achievement of successful miscarriage so our aim was to compare the effectiveness of vaginal versus sub-lingual misoprostol for medical treatment of first trimester missed miscarriage.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Contraception
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Group A (100 patients): will be treated with sublingual misoprostol
Drug: sublingual misoprostol
Group B (100 patients): will be treated with vaginal misoprostol
Drug: vaginal misoprostol
All patients will receive three doses of sublingual misoprostol every four hours The first dose of misoprostol 800 mcg will be administrated at the hospital. Then the patient will be observed for 1 hour for any immediate adverse reaction Clear instructions about the method and timing of second dose will be given upon sending home. * Two doses of misoprostol 800 mcg each (four tablets of 200 mcg per dose). * Paracetamol, eight hourly, will be provided as analgesic or antipyretic. * A specimen bottle to collect the POC if passed out. * Two pairs of disposable gloves. * Pre-filled histopathological examination form to be sent to the laboratory together with the products of conception
Also known as: Misotac
All patients will receive three doses of vaginal misoprostol every four hours The first dose of misoprostol 800 mcg will be administrated at the hospital. Then the patient will be observed for 1 hour for any immediate adverse reaction Clear instructions about the method and timing of second dose will be given upon sending home. Paracetamol, eight hourly, will be provided as analgesic or antipyretic
Also known as: Misotac
Completeness of abortion: expulsion of Products of conception (POC)x by visual inspection
Time frame: 7 days
Successful medical abortion: cervical os is closed with endometrial thickness of less than 15 mm
Time frame: 7 days
Failure: endometrial thickness of more than 15 mm on day seven (from third dose of misoprostol) or developing of complications before day seven needing early surgical evacuation.
Time frame: 7 days
Bleeding pattern following treatment
This will be assessed by hemoglobin(g/dl) and haematocrit level after the treatment , if the patients required blood transfusion and number of units transfused and number of days of bleeding
Time frame: 7 days
Pain resulting from the procedure
this will be assessed by the doses of paracetamol given in mg
Time frame: 7 days
Additional uterotonic used
additional misoprostol doses in mcg
Time frame: 7 days
Plan to share: Undecided
Ran from Jan 2016 to primary completion in Jan 2017, 12 months.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Aug 2017. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Misoprostol