An interventional study of Proton magnetic resonance spectroscopy (1H MRS) and a protein rich breakfast at home in Assay Muscle and Liver Glutathione in Healthy Human, sponsored by University Hospital, Clermont-Ferrand. Completed at 1 site in France. Open to participants aged 18 Days to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-07-26.
Sponsored by University Hospital, Clermont-Ferrand · Not applicable, Interventional, and Diagnostic
Glutathione (glutamyl-cysteinyl-glycine) is the main intracellular compound. It participates also in the detoxification of electrophiles molecules of which paracetamol. It is synthesized in the liver during the postprandial phase, which establishes a stock that is mobilized for the other tissues (muscle)during the postabsorptive period. It is of common knowledge that the decrease in glutathione concentrations associated with ageing could be involved in the development of the degenerative pathologies linked to the old age. These changes could be reversed by an increase in dietary cysteine, the amino acid limiting of the endogenous synthesis of GSH. The development of nutritional strategies aiming at an improvement of the status glutathione requires the determination of its concentration within tissues, where it is active. The quantification of tissue concentrations of glutathione by biochemical techniques requires tissue biopsies. Such a method can be performed for the muscle, but liver biopsy is not feasible outside of a surgery. It is necessary to set up a non-invasive method to quantify muscle and liver glutathione.
The study will validate the detection and the quantification of glutathione in muscle and liver using 1H MRS. The accuracy of the method will be assessed from intra and inter-volunteer measurements. 1H MRS measurements will be performed with the Magnetic Resonance Imaging (MRI) 3 Tesla system of the Hospital, twice for each volunteer.
Prior to the measurements, volunteers will have a protein rich breakfast at home and a protein rich lunch at the Clinical Investigation Center.
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The study will validate the detection and the quantification of glutathione in muscle and liver using 1H MRS
Device: Proton magnetic resonance spectroscopy (1H MRS) · Other: a protein rich breakfast at home · Other: a protein rich lunch at the Clinical Investigation Center
Signal-to-noise ratio of glutathione detected in liver and muscle
Time frame: 2 h after the lunch.
Glutathione concentrations in liver
Time frame: 2 h after the lunch
Glutathione concentrations in muscle
Time frame: 2 h after the lunch
Glutathione concentrations in means
Time frame: 2 h after the lunch
Glutathione concentrations in intervariabilities
Time frame: 2 h after the lunch
Glutathione concentrations in intravariabilities
Time frame: 2 h after the lunch
This study is completed, as verified in Jul 2016. You cannot join it, but the record below documents what was studied.
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University Hospital, Clermont-Ferrand