An interventional study of Whole-body compression in Severe Sepsis or Septic Shock and Fluid Resuscitation, sponsored by Centre Hospitalier Universitaire Dijon. Completed at 2 sites in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-02-09.
Sponsored by Centre Hospitalier Universitaire Dijon · Not applicable, Interventional, and Treatment
Early and adequate fluid resuscitation (\< 6 hours) in patients with circulatory failure is essential but may exacerbate oedema, which may itself: 1) aggravate pulmonary lesions and prolong mechanical ventilation, 2) aggravate organ failure and 3) increase mortality notably in patients with acute renal failure. Improving fluid balance is considered crucial in the management of patients in septic shock, but the efficacy of the measures currently proposed (diuretics associated or not with albumin and/or dialysis) is controversial. The investigators hypothesize that a whole-body compression using a body bandage could reduce capillary leakage and thus lead to faster restoration of a normal transmural pressure gradient in postcapillary venules and improve venous return.
This is the first study to evaluate mechanical compression using a body bandage to reduce oedema in septic shock.
To do this, a whole-body compression will be set up within the 12 hours following admission. Water balance will be monitored daily throughout the duration of the compression and vital status of patients will be search at 7 days, 28 days and 90 days.
1,899 studies on the registry are indexed under Sepsis; 462 are open to participants now.
This study's enrollment of 64 is below the median of 105 across 896 interventional studies indexed under Sepsis.
Browse Sepsis studies →Centre Hospitalier Universitaire Dijon is the lead sponsor of 495 studies on the registry; 105 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Fluid balance
Time frame: At 7 days
Plan to share: No
This study is completed, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.
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Centre Hospitalier Universitaire Dijon