An interventional study of Salmonella typhi vaccination and Placebo in Major Depression, sponsored by NHS Greater Glasgow and Clyde. Status unknown. Open to male participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-01-12.
Sponsored by NHS Greater Glasgow and Clyde · Not applicable, Interventional, and Basic science
Acquiring, processing and utilising "information" is crucial to any mental function -including seemingly simple daily functions. Collectively called 'cognitive functions', these processes are a result of different regions of the brain acting together.
Disruption of these cognitive functions increases the risk of development of mental health problem. Recently it has been proposed that inflammatory pathways may contribute to disorders of cognition and behaviour like depression.
This is largely due to research showing that those with inflammatory conditions like arthritis are more likely to develop mental health problems like depression. Conversely, those who suffer from mental health problems (even in the absence of inflammatory conditions) have large amounts of inflammatory molecules in the blood. Studies in animals suggest that inflammation outside the brain can reach and affect the brain in a number of ways. So, does inflammation play a role in the development of cognitive and behavioural symptoms? What are the pathways involved?
The current project tries to address this question. Specifically, the investigators intend to use modern scanning techniques to examine the effect of inducing a low grade inflammation (using a commonly used typhoid vaccine) to see how the inflammation affects how different regions of the act together to perform cognitive functions.
2,741 studies on the registry are indexed under Depressive Disorder, Major; 558 are open to participants now.
This study's planned enrollment of 20 is below the median of 80 across 2,282 interventional studies indexed under Depressive Disorder, Major.
Browse Depressive Disorder, Major studies →NHS Greater Glasgow and Clyde is the lead sponsor of 215 studies on the registry; 39 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Salmonella typhi vaccination
Biological: Salmonella typhi vaccination
0.9% sodium chloride
Biological: Placebo
Functional connectivity measured using resting state functional MRI BOLD time series cross correlations between the network nodes.
Time frame: 6 hours
Correlation of functional connectivity measures with circulating serum cytokines and POMS/ BDI scores using multivariate general linear models
Time frame: 6 hours
No study locations are listed for this record.
Plan to share: No
This study is status unknown, as verified in Jan 2016. You cannot join it, but the record below documents what was studied.
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NHS Greater Glasgow and Clyde