An interventional study of molecular analysis of exhaled breath condensate and molecular analysis of mini-bronchoalveolar lavage (BAL) aspirate in Ventilator Associated Pneumonia (VAP), sponsored by Vanderbilt University Medical Center. Terminated at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-08-04.
Sponsored by Vanderbilt University Medical Center · Not applicable, Interventional, and Diagnostic
To determine if the analysis of exhaled breath condensate correlates with the development \& resolution of pneumonia.
This proposal investigates the utility of exhaled breath condensate fluid (EBCF) collected from heat moisture exchange (HME) filters connected to patient's endotracheal tubes for early, non-invasive detection of ventilator-associated pneumonia (VAP) in critically ill or injured ICU patients. The development of pneumonia during mechanical ventilation is the most common healthcare-associated infection in severely injured patients, accounting for substantial morbidity, excess ICU and hospital stay, additional cost and increased mortality.
392 studies on the registry are indexed under Pneumonia, Ventilator-Associated; 81 are open to participants now.
This study's enrollment of 110 is close to the median of 122 across 254 interventional studies indexed under Pneumonia, Ventilator-Associated.
Browse Pneumonia, Ventilator-Associated studies →Vanderbilt University Medical Center is the lead sponsor of 824 studies on the registry; 164 are open to participants now.
Of its 122 completed or terminated interventional studies of FDA-regulated products, 91 (75%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
ventilated trauma patients with pneumonia
Procedure: molecular analysis of exhaled breath condensate · Procedure: molecular analysis of mini-bronchoalveolar lavage (BAL) aspirate · Procedure: molecular analysis of bronchoalveolar lavage (BAL) aspirate
ventilated trauma patients without pneumonia
Procedure: molecular analysis of exhaled breath condensate · Procedure: molecular analysis of mini-bronchoalveolar lavage (BAL) aspirate
ventilated surgical ICU patients with pneumonia
Procedure: molecular analysis of exhaled breath condensate · Procedure: molecular analysis of mini-bronchoalveolar lavage (BAL) aspirate · Procedure: molecular analysis of bronchoalveolar lavage (BAL) aspirate
ventilated surgical ICU patients without pneumonia
Procedure: molecular analysis of exhaled breath condensate · Procedure: molecular analysis of mini-bronchoalveolar lavage (BAL) aspirate
The number of patients with a positive association between the exhaled breath condensate fluid and BAL fluid in in patients suspected of pneumonia.
To determine the association between the microbial community in both EBCF specimens and bronchoalveolar lavage fluid (BALF) samples in critically ill and injured, mechanically ventilated patients suspected of VAP.
Time frame: enrollment to hospital day 15
The per cent of positive correlation for the development & resolution of pneumonia based on changes in bacteria found in the exhaled breath condensate.
To develop a robust predictive model for the development of VAP and its resolution based on changes in the microbial community in EBCF collected over the course of ventilation.
Time frame: enrollment to hospital day 15
Plan to share: No
No publications or documents are linked to this record.
This study is terminated, as verified in Aug 2022. You cannot join it, but the record below documents what was studied.
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Pneumonia, Ventilator-Associated→
Vanderbilt University Medical Center