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CompletedNCT02650531Nor-CoastUpdated Feb 23, 2022

Norwegian COgnitive Impairment After STroke (NorCOAST) Study

An observational study in Dementia, Mild Cognitive Impairment and Stroke, sponsored by Norwegian University of Science and Technology. Completed at 1 site in Norway. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-02-23.

Sponsored by Norwegian University of Science and Technology · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
816
Ages
18 Years and older
Sex
All
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Study summary

A prospective observational multicenter study aiming to describe incidence, and identify predictors for development of poststroke dementia (PSD) and mild cognitive impairment (MCI) after stroke

Read the detailed description

About 15000 Norwegians suffer a stroke every year and 2/3 will be more or less disabled. In addition to motor impairments and comorbidities, disability after stroke is often related to post stroke dementia (PSD) or mild neurocognitive disorder (NCD). However, these problems are hardly addressed in stroke or dementia research and frequently ignored in clinical practise. In the Nor-COAST study an interdisciplinary research group will collaborate to establish a research platform across all Norwegian Health Authorities. The overall aim of the study is to improve competence on PSD and NCD in order to improve individual health outcomes following a stroke. The specific objectives are to determine the incidence of PSD and NCD and the consequences on function and use of health care services and to enhance the early detection of PSD and NCD by identifying a set of risk factors, ranging from genetics to physical activity. The incidence and impact of PSD and NCD on function and use of health care services, medication and life-style changes are important when planning future health care services. Tools identifying patients at risk might improve diagnostic work up and together with knowledge on pathogenic aspects it will contribute to future treatment and prevention of PSD and NCD.

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Conditions studied

  • Dementia
  • Mild Cognitive Impairment
  • Stroke

Keywords

  • Follow up studies
  • Risk factors
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In context

Stroke

7,286 studies on the registry are indexed under Stroke; 2,007 are open to participants now.

This study's enrollment of 816 is above the median of 160 across 1,692 observational studies indexed under Stroke.

Browse Stroke studies →

Lead sponsor

Norwegian University of Science and Technology is the lead sponsor of 487 studies on the registry; 52 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Patients with acute stroke

Inclusion criteria

  • Stroke diagnosis according to the WHO criteria

Exclusion criteria

Exclusion Criteria:

  • Not scandinavian speaking
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
816 participants (actual)
Patient registry
No
Biospecimen retention
Samples with dna
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What researchers measure

Primary outcomes

  1. Score on the Montreal cognitive assessment (MOCA)

    Performance based test

    Time frame: 18 months

Secondary outcomes

  1. Score on the Montreal cognitive assessment (MOCA)

    Performance based test

    Time frame: 3 months

  2. Time spent in upright position

    measured by bodyworn sensors

    Time frame: 3 months

  3. Time spent in upright position

    measured by bodyworn sensors

    Time frame: 18 months

  4. Brain Imaging

    MRI

    Time frame: 18 months

  5. Score on Short Physical Performance Battery (sppb)

    Performance based test for mobility and lower extremity function

    Time frame: 3 months

  6. Score on Short Physical Performance Battery (sppb)

    Physical function by performance based tests

    Time frame: 18 months

  7. Selfreported habits concerning smoking, alcohol, diet and medication using standardised questionnaires

    Time frame: 3 months

  8. Selfreported habits concerning smoking, alcohol, diet and medication using standardised questionnaires

    Time frame: 18 months

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Study locations

1 site
  • Norwegian University of Science and Technology
    Trondheim, 7006, Norway
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References and documents

Publications

  • Thingstad P, Askim T, Beyer MK, Brathen G, Ellekjaer H, Ihle-Hansen H, Knapskog AB, Lydersen S, Munthe-Kaas R, Naess H, Pendlebury ST, Seljeseth YM, Saltvedt I. The Norwegian Cognitive impairment after stroke study (Nor-COAST): study protocol of a multicentre, prospective cohort study. BMC Neurol. 2018 Nov 26;18(1):193. doi: 10.1186/s12883-018-1198-x. PubMed 30477436 ↗
  • Waehler IS, Saltvedt I, Lydersen S, Fure B, Askim T, Einstad MS, Thingstad P. Association between in-hospital frailty and health-related quality of life after stroke: the Nor-COAST study. BMC Neurol. 2021 Mar 4;21(1):100. doi: 10.1186/s12883-021-02128-5. PubMed 33663430 ↗
  • Gynnild MN, Hageman SHJ, Spigset O, Lydersen S, Saltvedt I, Dorresteijn JAN, Visseren FLJ, Ellekjaer H. Use of lipid-lowering therapy after ischaemic stroke and expected benefit from intensification of treatment. Open Heart. 2022 Apr;9(1):e001972. doi: 10.1136/openhrt-2022-001972. PubMed 35459718 ↗
  • Munthe-Kaas R, Aam S, Saltvedt I, Wyller TB, Pendlebury ST, Lydersen S, Hagberg G, Schellhorn T, Rostoft S, Ihle-Hansen H. Is Frailty Index a better predictor than pre-stroke modified Rankin Scale for neurocognitive outcomes 3-months post-stroke? BMC Geriatr. 2022 Feb 19;22(1):139. doi: 10.1186/s12877-022-02840-y. PubMed 35183106 ↗
  • Einstad MS, Thingstad P, Lydersen S, Gunnes M, Saltvedt I, Askim T. Physical Performance and Cognition as Predictors of Instrumental Activities of Daily Living After Stroke: A Prospective Multicenter Cohort Study. Arch Phys Med Rehabil. 2022 Jul;103(7):1320-1326. doi: 10.1016/j.apmr.2022.01.153. Epub 2022 Feb 16. PubMed 35181266 ↗
  • Alme KN, Ulvik A, Askim T, Assmus J, Mollnes TE, Naik M, Naess H, Saltvedt I, Ueland PM, Knapskog AB. Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke. BMC Neurol. 2021 Dec 8;21(1):476. doi: 10.1186/s12883-021-02498-w. PubMed 34879833 ↗
  • Alme KN, Askim T, Assmus J, Mollnes TE, Naik M, Naess H, Saltvedt I, Ueland PM, Ulvik A, Knapskog AB. Investigating novel biomarkers of immune activation and modulation in the context of sedentary behaviour: a multicentre prospective ischemic stroke cohort study. BMC Neurol. 2021 Aug 16;21(1):318. doi: 10.1186/s12883-021-02343-0. PubMed 34399717 ↗
  • Schellhorn T, Zucknick M, Askim T, Munthe-Kaas R, Ihle-Hansen H, Seljeseth YM, Knapskog AB, Naess H, Ellekjaer H, Thingstad P, Wyller TB, Saltvedt I, Beyer MK. Pre-stroke cognitive impairment is associated with vascular imaging pathology: a prospective observational study. BMC Geriatr. 2021 Jun 14;21(1):362. doi: 10.1186/s12877-021-02327-2. PubMed 34126944 ↗
  • Schellhorn T, Aamodt EB, Lydersen S, Aam S, Wyller TB, Saltvedt I, Beyer MK. Clinically accessible neuroimaging predictors of post-stroke neurocognitive disorder: a prospective observational study. BMC Neurol. 2021 Feb 25;21(1):89. doi: 10.1186/s12883-021-02117-8. PubMed 33632149 ↗
  • Einstad MS, Saltvedt I, Lydersen S, Ursin MH, Munthe-Kaas R, Ihle-Hansen H, Knapskog AB, Askim T, Beyer MK, Naess H, Seljeseth YM, Ellekjaer H, Thingstad P. Associations between post-stroke motor and cognitive function: a cross-sectional study. BMC Geriatr. 2021 Feb 5;21(1):103. doi: 10.1186/s12877-021-02055-7. PubMed 33546620 ↗
  • Munthe-Kaas R, Aam S, Saltvedt I, Wyller TB, Pendlebury ST, Lydersen S, Ihle-Hansen H. Test Accuracy of the Montreal Cognitive Assessment in Screening for Early Poststroke Neurocognitive Disorder: The Nor-COAST Study. Stroke. 2021 Jan;52(1):317-320. doi: 10.1161/STROKEAHA.120.031030. Epub 2020 Nov 30. Erratum In: Stroke. 2022 May;53(5):e218. doi: 10.1161/STR.0000000000000408. PubMed 33250039 ↗
  • Alme KN, Knapskog AB, Naess H, Naik M, Beyer M, Ellekjaer H, English C, Hansen HI, Kummeneje CS, Munthe-Kaas R, Saltvedt I, Seljeseth Y, Tan X, Thingstad P, Askim T. Is long-bout sedentary behaviour associated with long-term glucose levels 3 months after acute ischaemic stroke? A prospective observational cohort study. BMJ Open. 2020 Nov 26;10(11):e037475. doi: 10.1136/bmjopen-2020-037475. PubMed 33243789 ↗
  • Gynnild MN, Aakeroy R, Spigset O, Askim T, Beyer MK, Ihle-Hansen H, Munthe-Kaas R, Knapskog AB, Lydersen S, Naess H, Rosstad TG, Seljeseth YM, Thingstad P, Saltvedt I, Ellekjaer H. Vascular risk factor control and adherence to secondary preventive medication after ischaemic stroke. J Intern Med. 2021 Mar;289(3):355-368. doi: 10.1111/joim.13161. Epub 2020 Aug 19. PubMed 32743852 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 23, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02650531
Lead sponsor
Norwegian University of Science and Technology
Collaborators
Ullevaal University Hospital, Vestre Viken Hospital Trust, Haukeland University Hospital, University Hospital of North Norway
Responsible party
Sponsor
First posted
Jan 8, 2016
Start date
May 2015
Primary completion
Oct 8, 2018
Completion
Oct 8, 2018
Last update
Feb 23, 2022

Study contacts

Lars Jacob Stovner, md prof
study director · Norwegian University of Science and Technology

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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