An observational study in Polyps, sponsored by Western Sydney Local Health District. Completed at 1 site in Australia. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2021-03-23.
Sponsored by Western Sydney Local Health District · Observational
The development of a standardised imaging protocol to detect post endoscopic mucosal resection (EMR) recurrence or residual adenoma through the comparison of biopsies of the post EMR scar with endoscopic findings.
Removal of colonic polyps reduces colon cancer and although most polyps found are small, removal of large polyps can now be safely and effectively removed with wide field EMR. Residual polyp tissue is found at follow up colonoscopy in approximately 15% of cases however and remains a focus of attempts to improve EMR efficacy. All patients undergoing surveillance colonoscopy after EMR at Westmead Hospital Endoscopy unit will have steps of assessment and therapy of the scar recorded. Data will be entered into the large prospective audit database and also analysed separately. Data will be stored in coded format. The individual steps and the outcome of the scar interrogation and therapy will also be assessed and analysed. It is expected that these results will help guide the optimal approach to assessment and confirm the efficacy of therapy of recurrence further aiding the endoscopic approach to large colonic polyps.
Western Sydney Local Health District is the lead sponsor of 35 studies on the registry; 18 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients who have had endoscopic mucosal resection of colonic polyps that are undergoing surveillance colonoscopy.
Exclusion Criteria:
Patients who are referred for Endoscopic Mucosal Resection of Upper Gastrointestinal Lesions undertaking a surveillance visit will be included in this cohort.
Presence of post-EMR recurrence
Presence of post-EMR recurrence
Time frame: one year
Histological characteristics of post-EMR scar biopsies
Time frame: one year
Scar size
Scar size (maximum dimension)
Time frame: one year
Presence of post EMR scar with clip artifact
Presence of post EMR scar with clip artifact, recognized as one or more nodule within the scar with a normal pit pattern
Time frame: one year
Number of sites of recurrence
Number of sites of recurrence (unifocal, 2 sites, 3 or more sites)
Time frame: one year
Location of recurrence
Location of recurrence (edge of the scar, within the scar or both)
Time frame: one year
Morphology of recurrence
Morphology of recurrence (flat or elevated)
Time frame: one year
Kudo pit pattern assessment
Kudo pit pattern and whether the pit pattern of recurrence is only seen with NBI
Time frame: one year
NICE classification
As recurrence is diminutive the NICE classification is also applied and so the NBI appearance of recurrence (darker or lighter than the scar) is noted.
Time frame: one year
This study is completed, as verified in Mar 2021. You cannot join it, but the record below documents what was studied.
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Western Sydney Local Health District