An interventional study of Priming of ECMO circuit with 0.9% NaCl and Priming of ECMO circuit with Ringer Lactate in Acute Respiratory Failure, sponsored by Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico. Status unknown at 1 site in Italy. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2015-11-20.
Sponsored by Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · Not applicable, Interventional, and Basic science
Crystalloid solutions modify acid-base equilibrium according to their electrolyte composition. Moreover, it has been suggested that these alterations are generated by the difference between the solution strong ion difference (SID) and the plasma bicarbonate level. An increased risk of acute kidney injury and renal replacement therapy has been associated to the infusion of chloride rich crystalloids. This study aims to compare, in patients with acute respiratory failure undergoing ECMO support, the effects on acid-base status and renal function of crystalloids commonly employed for circuit priming to a balanced solution created with a SID equal to patients' bicarbonate level.
1,650 studies on the registry are indexed under Respiratory Insufficiency; 296 are open to participants now.
This study's planned enrollment of 45 is below the median of 55 across 1,043 interventional studies indexed under Respiratory Insufficiency.
Browse Respiratory Insufficiency studies →Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico is the lead sponsor of 214 studies on the registry; 71 are open to participants now.
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Exclusion Criteria:
Circuit priming will be performed with 0.9% NaCl solution
Other: Priming of ECMO circuit with 0.9% NaCl
Circuit priming will be performed with Ringer Lactated
Other: Priming of ECMO circuit with Ringer Lactate
Circuit priming will be performed with a Balanced Solution created by mixing 0.9% NaCl, Sodium bicarbonate (8.4%) and injectable sterile water, in order to obtain a solution with constant sodium concentration (140 mEq/l) and SID equal to patient's bicarbonate level.
Other: Priming of ECMO circuit with Balanced Solution
0.9% NaCl as priming crystalloid solution
Ringer Lactate as priming crystalloid solution
Balanced Solution as priming crystalloid solution
Variation in Acid-Base Equilibrium (Base Excess)
Time frame: First 24 hours after ECMO start
Variation in Acid-Base Equilibrium (pH)
Time frame: First 24 hours after ECMO start
Variation in Renal Function
Time frame: First 24 hours after ECMO start
This study is status unknown, as verified in Nov 2015. You cannot join it, but the record below documents what was studied.
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Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico