An interventional study of Clinical and neuropsychological evaluation procedure in Perinatal Listeriosis, sponsored by Assistance Publique - Hôpitaux de Paris. Completed at 1 site in France. Open to participants aged 5 Years to 6 Years. Per ClinicalTrials.gov, last updated 2025-09-11.
Sponsored by Assistance Publique - Hôpitaux de Paris · Not applicable, Interventional, and Diagnostic
The purpose of the study is to determine whether perinatal listeriosis is associated with long-term neurological consequences, and to evaluate the respective contribution of perinatal sepsis, of prematurity and of the known neurological tropism of the involved pathogen, Listeria monocytogenes.
Perinatal listeriosis is defined by the occurrence of maternal listeriosis at birth and/or of early-onset listeriosis in the neonate (defined by the positive culture of any sample of maternal or neonatal origin).
Neurological involvement is defined by the presence of inflammation of the cerebrospinal fluid of positive culture or the cerebro-spinal fluid.
Evaluation is performed at the age of 5 years, and includes WPPSI evaluation of the Intelligence Quotient (IQ), NEPSY evaluation of the executive functions and clinical evaluation checking for any motor, sensorial or other focal deficiency among 90 cases and 270 controls matched for gestational age.
198 studies on the registry are indexed under Neurologic Manifestations; 67 are open to participants now.
This study's enrollment of 53 is above the median of 40 across 107 interventional studies indexed under Neurologic Manifestations.
Browse Neurologic Manifestations studies →Assistance Publique - Hôpitaux de Paris is the lead sponsor of 3,505 studies on the registry; 1,006 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Clinical and neuropsychological evaluation procedure 90 children
Other: Clinical and neuropsychological evaluation procedure
Cohort of prematurely borne children and their controls Clinical and neuropsychological evaluation procedure 270 children
Other: Clinical and neuropsychological evaluation procedure
WPPSI, NEPSY, Brief, SDQ, Vineland and SCQ evaluation Clinical examination
Reduction of > 20 points of the Intellectual Quotient
Evaluated by standard tests (WPPSI-IV)
Time frame: Day 1
Score obtained at M-ABC evaluation test (Movement-ABC)
to evaluate alteration of executive functions
Time frame: Day 1
Score obtained at SDQ evaluation test (Strenghts and Difficulties Questionnaire)
to evaluate alteration of cognitive functions
Time frame: Day 1
Score obtained at SCQ evaluation test (Social Communication Questionnaire)
to evaluate alteration of cognitive functions
Time frame: Day 1
Score obtained at BRIEF-P evaluation test (Behavior Rating Inventoring Executive Function)
to evaluate alteration of executive functions
Time frame: Day 1
Score obtained at HOME evaluation test (Home Observation and Measurement of Environment)
Time frame: Day 1
Score obtained at Vineland Scale
Time frame: Day 1
Scores obtained at NEPSY-2 evaluation tests
Time frame: Day 1
This study is completed, as verified in Sep 2025. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Assistance Publique - Hôpitaux de Paris