An interventional study of Vascular flow measurement by PC-MRI in Alzheimer Disease, sponsored by Central Hospital Saint Quentin. Status unknown at 1 site in France. Open to participants aged 75 Years to 120 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-07-14.
Sponsored by Central Hospital Saint Quentin · Not applicable, Interventional, and Diagnostic
Obstructive sleep apnea syndrome (OSAS) is a sleep-disordered breathing characterized by the occurrence of repeated upper airway obstructions leading to airflow reduction (hypopnea) or cessation (apnea). The apnea-hypopnea index (AHI) is the number of apneas and hypopneas per hour of sleep. OSA patients often report cognitive complaints.
About 25% of the elderly population is affected by this syndrome with a drastic increase of this rate among dementia patients. OSAS is considered to be an important risk factor for the development of hypertension, heart disease and stroke.
Numerous studies pointed out the close relationship between sleep apnea and cognitive impairment. To the investigators' knowledge, no trials have assessed the existence of a relationship between the IAH index and the cerebral arterial blood flow rate (macrocirculation). Developments in magnetic resonance imaging (MRI) provide new insights into the quantitative study of blood flow through phase contrast MRI also called "flow MRI". The main hypothesis tested in this study is the existence of a relationship between OSAS and total cerebral arterial vascular inflow measured by PC-MRI (in mL/min) in the elderly population.
Secondary outcomes:
Dementia Group:
3.1. MMSE (Mini Mental State Examination)> 15
3.2. Diagnosis of dementia established according to DSM-IV
3.3. Dementia of the Alzheimer type from NINCDS-ADRDA (National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association)
Control Group:
Preserved cognitive function corresponding to a normal MMSE score by the standards of Poitrenaud
Exclusion Criteria:
Anyone with a classic contraindication to MRI
2.1 Major behavioral disorders that do not allow the realization of MRI in optimal conditions
2.2 Claustrophobia
2.3 Presence of foreign non-compliant material
2.4 Presence of intraocular metal body
Assessed by the insertion of an interaction parameter between cerebral blood flow and the group label(dementia or no-dementia). ROC method will be used to find a threshold value of IAH that separates the two groups. Interventions: * Vascular flow measurement by PC-MRI * Neuropsychological assessment * Registration of sleep apnea * Registration of blood pressure * ECG holters * Blood test * Geriatric standard evaluation
Other: Vascular flow measurement by PC-MRI
Assessed by the insertion of an interaction parameter between cerebral blood flow and the group label(dementia or no-dementia). ROC method will be used to find a threshold value of IAH that separates the two groups. Interventions: * Vascular flow measurement by PC-MRI * Neuropsychological assessment * Registration of sleep apnea * Registration of blood pressure * ECG holters * Blood test * Geriatric standard evaluation
Other: Vascular flow measurement by PC-MRI
participants will undergo vascular flow measurement by PC-MRI at intra and extracranial levels
Total arterial flowrate (measured by PC-MRI debit ml/Mn)
Time frame: at day 1 after inclusion
sleep apnea measured by elderly polygraphy (Number of apneas / night)
Time frame: at day 1 after inclusion up to 24 heures
Plan to share: No
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Central Hospital Saint Quentin