An interventional study of alveolar recruitment maneuvers group 1 and alveolar recruitment maneuvers group 2 in Cerebral Injuries and Acute Respiratory Distress Syndrome (ARDS), sponsored by University Hospital, Toulouse. Terminated at 5 sites in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-06-01.
Sponsored by University Hospital, Toulouse · Not applicable, Interventional, and Treatment
This study aims to compare 2 alveolar recruitment maneuvers (ARM) in patients with cerebral injuries and acute respiratory distress syndrome (ARDS) in term of efficacy and tolerance.
Two ARM are compared in this study:
Patients are randomized to receive in cross-over 2 ARM: CPAP and Extended Sigh (eSigh). The following data: oxygen tissue partial pressure (PtiO2), respiratory parameters, systemic and intracerebral hemodynamic parameters are collected before, after 1 minute, 10 minutes and 60 minutes for each ARM.
1,597 studies on the registry are indexed under Respiratory Distress Syndrome; 312 are open to participants now.
This study's enrollment of 18 is below the median of 60 across 961 interventional studies indexed under Respiratory Distress Syndrome.
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Exclusion Criteria:
alveolar recruitment maneuvers by CPAP then alveolar recruitment maneuvers by eSigh
Other: alveolar recruitment maneuvers group 1
alveolar recruitment maneuvers by eSigh then alveolar recruitment maneuvers by CPAP
Other: alveolar recruitment maneuvers group 2
Patients are randomized to receive in cross-over 2 ARM: CPAP at first and then eSigh. The continuous positive airway pressure, or CPAP with application of a positive pressure of 40 cmH2O for 40 seconds without tidal volume. The eSigh or extended sigh with increase of PEEP for 10 minutes to maintain plateau pressure at 40 cmH2O. During ARM, the peak pressure is limited to 50 cmH2O with decrease of tidal volume (Vt) if necessary. The following data: PtiO2, respiratory parameters, systemic and intracerebral hemodynamic parameters are collected before, after 1 minute, 10 minutes and 60 minutes for each ARM.
Patients are randomized to receive in cross-over 2 ARM: eSigh at first and then CPAP. The eSigh or extended sigh with increase of PEEP for 10 minutes to maintain plateau pressure at 40 cmH2O. During ARM, the peak pressure is limited to 50 cmH2O with decrease of tidal volume (Vt) if necessary. The continuous positive airway pressure, or CPAP with application of a positive pressure of 40 cmH2O for 40 seconds without tidal volume. The following data: PtiO2, respiratory parameters, systemic and intracerebral hemodynamic parameters are collected before, after 1 minute, 10 minutes and 60 minutes for each ARM.
Comparison of oxygen tissue partial pressure (PtiO2) values
The comparison of PtiO2 values (mmHg, mean ± SD) 60 minutes after the 2 ARM: eSigh and CPAP
Time frame: 60 minutes
Comparison of systemic hemodynamic parameters
Comparison between the two ARM of systemic hemodynamic parameters: mean arterial pressure, heart rate and cardiac output.
Time frame: 60 minutes
Comparison of Intracranial hemodynamic parameters
Comparison between the two ARM of Intracranial hemodynamic parameters: ICP (Intracranial pressure) , cerebral perfusion pressure and Transcranial Doppler (pulsatility index, mean, systolic and diastolic velocities)
Time frame: 60 minutes
Comparison of blood oxygen level
Comparison between the two ARM of haematosis: Blood oxygen level (SpO2)
Time frame: 60 minutes
Comparison of partial pressure of carbon dioxide
Comparison between the two ARM of partial pressure of carbon dioxide (PaCO2),
Time frame: 60 minutes
Comparison of arterial blood gases
Comparison between the two ARM of arterial blood gases (partial pressure of oxygen (PaO2),
Time frame: 60 minutes
Comparison of end-tidal CO2
Comparison between the two ARM of end-tidal CO2
Time frame: 60 minutes
Comparison of Respiratory parameters
Comparison between the two ARM of Respiratory parameters: plateau pressure and static lung compliance.
Time frame: 60 minutes
Comparison of PtiO2
Comparison between the two ARM of PtiO2
Time frame: 60 minutes
This study is terminated, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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Respiratory Distress Syndrome→
University Hospital, Toulouse