An observational study in Hypertension, sponsored by Neuromed IRCCS. Status unknown at 1 site in Italy. Open to participants aged 30 Years to 85 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-04-11.
Sponsored by Neuromed IRCCS · Observational
The purpose of this study is to evaluate the splenic activation in hypertensive patients, as compared to normotensives, using FDG-PET/CT imaging. Moreover, the investigators will investigate whether the splenic metabolic activity relates to the expression of circulating inflammatory proteins (high-sensitivity C-reactive protein [hsCRP]), interleukin-1b (IL-1b), tumor necrosis factor-a (TNF-a) or to immune profiles of activated T cells.
6,689 studies on the registry are indexed under Hypertension; 965 are open to participants now.
This study's planned enrollment of 120 is below the median of 210 across 1,359 observational studies indexed under Hypertension.
Browse Hypertension studies →Neuromed IRCCS is the lead sponsor of 76 studies on the registry; 23 are open to participants now.
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Subjects will be selected from patients who will undergo FDG-PET/CT imaging of chest and abdomen in the Department of Nuclear Medicine of IRCCS Neuromed, accordingly to the following inclusion/exclusion criteria. All the enrolled patients must have an indication for FDG-PET/CT. Approximately 120 hypertensive and normotensive subjects of both genders (at least 45 per group, in order to have the appropriate statistical power) will be included in the study.
Exclusion Criteria:
Normotensive subjects
Other: PET/CT scan
Hypertensive subjects
Other: PET/CT scan
PET/CT scan
Splenic metabolic activity
18FDG uptake in splenic tissue
Time frame: At enrollment
Circulating pro-inflammatory markers
Serum levels of pro-inflammatory cytokines
Time frame: At enrollment
This study is status unknown, as verified in Apr 2022. You cannot join it, but the record below documents what was studied.
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Neuromed IRCCS