An observational study in Cystic Fibrosis, sponsored by University Hospital, Tours. Completed at 1 site in France. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-09-30.
Sponsored by University Hospital, Tours · Observational
The study is defined in 3 stages of in vitro assays :
Phase 1 : Secretion of NETs in response to lung disease and their secretion of factors.
This is a transversal study in which we compare :
Phase 2: Mechanisms of activation of NETs secretory pathways . This phase will identify receptors (TLR ) involved in the secretion of NETs and analyze the involvement of dependent transduction pathways calcium and PKC . It will be performed on control blood neutrophils.
Phase 3: Analysis of cell death ( NETose )
This is a transversal study that will analyze :
the mode of cell death of neutrophils purified blood and sputum of patients and control blood neutrophils by flow cytometry and transmission electron microscopy .
1,581 studies on the registry are indexed under Cystic Fibrosis; 190 are open to participants now.
This study's enrollment of 55 is below the median of 85 across 482 observational studies indexed under Cystic Fibrosis.
Browse Cystic Fibrosis studies →University Hospital, Tours is the lead sponsor of 304 studies on the registry; 78 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Pathophysiological study comparing a " Cystic fibrosis " group to a control group (adults)
Patients :
Volunteers :
Exclusion Criteria:
Patients :
Volunteers :
Control
Adult with cystic fibrosis
the DNA concentration secreted into the extracellular environment neutrophil activated
Time frame: 1 hour
This study is completed, as verified in Sep 2015. You cannot join it, but the record below documents what was studied.
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University Hospital, Tours