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CompletedNCT02563626CAARUpdated Jan 25, 2022

Coronary Artery Aneurysm Registry

An observational study in Coronary Artery Aneurysm, sponsored by St Carlos Hospital, Madrid, Spain. Completed at 1 site in Spain. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-01-25.

Sponsored by St Carlos Hospital, Madrid, Spain · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
1,565
Ages
18 Years and older
Sex
All
01

Study summary

International registry gathering patients with angiographically confirmed coronary aneurysm.

Read the detailed description

INTRODUCTION AND RATIONALE:

Coronary artery aneurysm is defined as coronary dilatation which exceeds the diameter of normal adjacent segments or the diameter of the patient's largest coronary vessel by 1.5 times. Described by Bourgon, it is an uncommon disease which has been diagnosed with increasing frequency since the advent of coronary angiography. The incidence varies from 1.5% to 5% with male dominance and a predilection for the right coronary artery.

Although several causes have been reported, atherosclerosis accounts for 50% of coronary aneurysms in adults. Reported complications include thrombosis and distal embolization, rupture and vasospasm, causing ischemia, heart failure or arrhythmias. The natural history and prognosis remains obscure, since definitive data are scarce. Controversies persist regarding the use of medical management (antithrombotic) or interventional/surgical procedures.

OBJECTIVES.

Taking into account the classical coronary aneurysm definition, the investigators propose:

  • ANATOMIC OBJECTIVES.

    • To characterize coronary aneurysms frequency over all cause invasive coronary angiography.
    • To describe anatomy, location and aneurysms features.
    • To assess intracoronary imaging data if available.
    • To describe the natural history, when evolutive chats were available

  • CLINICAL OBJECTIVES.

    • Cause for the diagnostic catheterization and aneurysms symptoms, if present.
    • Patient´s clinical features.
    • Long-term outcomes.

  • THERAPEUTIC OBJECTIVES.

    • To assess management strategies, conservative, interventional or surgical and its short and long term results.
    • Outcomes regarding management.

DESIGN:

  • Retrospective recruitment, prospective follow-up registry.
  • Multicentric/international.
  • Anonymized.
  • Electronic database. Centralized analysis (core) at Hospital Clínico San Carlos.
  • Recruitment: 1/january/2002-1/december/2015.
02

Conditions studied

  • Coronary Artery Aneurysm

Keywords

  • coronary artery aneurysm
  • prognosis
  • outcomes
  • management
  • incidence
  • heart failure
  • acute coronary syndrome
  • death
03

In context

Aneurysm

960 studies on the registry are indexed under Aneurysm; 175 are open to participants now.

This study's enrollment of 1,565 is above the median of 151 across 443 observational studies indexed under Aneurysm.

Browse Aneurysm studies →

Lead sponsor

St Carlos Hospital, Madrid, Spain is the lead sponsor of 3 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

All patients with a coronary aneurysm diagnosis.

Inclusion criteria

  • Coronary aneurysm: focal coronary dilatation which exceeds the diameter of normal adjacent segments or the diameter of the patient's largest coronary vessel by 1.5 times.

Exclusion criteria

Exclusion Criteria:

  • Patient ´s refusal to participate.
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
1,565 participants (actual)
Target follow-up
12 Months
Patient registry
Yes
06

What researchers measure

Primary outcomes

  1. Any cause death

    dicotomic variable (yes/no)

    Time frame: 12 months

  2. Cardiology readmission

    dicotomic variable (yes/no)

    Time frame: 12 months

07

Study locations

1 site
  • Hospital Clínico San Carlos
    Madrid, 28040, Spain
08

References and documents

Publications

  • SCOTT DH. Aneurysm of the coronary arteries. Am Heart J. 1948 Sep;36(3):403-21. doi: 10.1016/0002-8703(48)90337-8. No abstract available. PubMed 18880707 ↗
  • Swaye PS, Fisher LD, Litwin P, Vignola PA, Judkins MP, Kemp HG, Mudd JG, Gosselin AJ. Aneurysmal coronary artery disease. Circulation. 1983 Jan;67(1):134-8. doi: 10.1161/01.cir.67.1.134. PubMed 6847792 ↗
  • Syed M, Lesch M. Coronary artery aneurysm: a review. Prog Cardiovasc Dis. 1997 Jul-Aug;40(1):77-84. doi: 10.1016/s0033-0620(97)80024-2. PubMed 9247557 ↗
  • Dutary J, Zakhem B, DE Lucas CB, Paulo M, Gonzalo N, Alfonso F. Treatment of a giant coronary artery aneurysm: intravascular ultrasound and optical coherence tomography findings. J Interv Cardiol. 2012 Feb;25(1):82-5. doi: 10.1111/j.1540-8183.2011.00659.x. Epub 2011 May 22. PubMed 21599751 ↗
  • Maehara A, Mintz GS, Ahmed JM, Fuchs S, Castagna MT, Pichard AD, Satler LF, Waksman R, Suddath WO, Kent KM, Weissman NJ. An intravascular ultrasound classification of angiographic coronary artery aneurysms. Am J Cardiol. 2001 Aug 15;88(4):365-70. doi: 10.1016/s0002-9149(01)01680-0. PubMed 11545755 ↗
  • Nunez-Gil IJ, Nombela-Franco L, Bagur R, Bollati M, Cerrato E, Alfonso E, Liebetrau C, De la Torre Hernandez JM, Camacho B, Mila R, Amat-Santos IJ, Alfonso F, Rodriguez-Olivares R, Camacho Freire SJ, Lozano I, Jimenez Diaz VA, Piraino D, Latini RA, Feltes G, Linares JA, Mancone M, Ielasi A, Sanchez-Grande Flecha A, Fernandez Cisnal A, Ugo F, Jimenez Mazuecos JM, Omede P, Pavani M, Villablanca PA, Louka BF, Fernandez-Ortiz A; CAAR Investigators. Rationale and design of a multicenter, international and collaborative Coronary Artery Aneurysm Registry (CAAR). Clin Cardiol. 2017 Aug;40(8):580-585. doi: 10.1002/clc.22705. Epub 2017 Mar 24. PubMed 28337781 ↗
  • Nunez-Gil IJ, Cerrato E, Bollati M, Nombela-Franco L, Terol B, Alfonso-Rodriguez E, Camacho Freire SJ, Villablanca PA, Amat Santos IJ, de la Torre Hernandez JM, Pascual I, Liebetrau C, Camacho B, Pavani M, Albistur J, Latini RA, Varbella F, Jimenez-Diaz VA, Piraino D, Mancone M, Alfonso F, Linares JA, Rodriguez-Olivares R, Jimenez Mazuecos JM, Palazuelos Molinero J, Sanchez-Grande Flecha A, Gomez-Hospital JA, Ielasi A, Lozano I, Omede P, Bagur R, Ugo F, Medda M, Louka BF, Kala P, Escaned J, Bautista D, Feltes G, Salinas P, Alkhouli M, Macaya C, Fernandez-Ortiz A; CAAR investigators. Coronary artery aneurysms, insights from the international coronary artery aneurysm registry (CAAR). Int J Cardiol. 2020 Jan 15;299:49-55. doi: 10.1016/j.ijcard.2019.05.067. Epub 2019 Jul 19. PubMed 31378382 ↗
  • D'Ascenzo F, Saglietto A, Ramakrishna H, Andreis A, Jimenez-Mazuecos JM, Nombela-Franco L, Cerrato E, Liebetrau C, Alfonso-Rodriguez E, Bagur R, Alkhouli M, De Ferrari GM, Nunez-Gil IJ; CAAR Investigators. Usefulness of oral anticoagulation in patients with coronary aneurysms: Insights from the CAAR registry. Catheter Cardiovasc Interv. 2021 Nov 1;98(5):864-871. doi: 10.1002/ccd.29243. Epub 2020 Sep 9. PubMed 32902099 ↗
  • Arslan F, Nunez-Gil IJ, Rodriguez-Olivares R, Cerrato E, Bollati M, Nombela-Franco L, Terol B, Alfonso-Rodriguez E, Camacho Freire SJ, Villablanca PA, Amat Santos IJ, De la Torre Hernandez JM, Pascual I, Liebetrau C, Alkhouli M, Fernandez-Ortiz A; Coronary Artery Aneurysm Registry (CAAR) investigators. Sex differences in treatment strategy for coronary artery aneurysms: Insights from the international Coronary Artery Aneurysm Registry. Neth Heart J. 2022 Jun;30(6):328-334. doi: 10.1007/s12471-021-01649-5. Epub 2021 Dec 15. PubMed 34910278 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 25, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02563626
Lead sponsor
St Carlos Hospital, Madrid, Spain
Responsible party
IVAN J NUÑEZ GIL (MD, PhD, FESC, St Carlos Hospital, Madrid, Spain) — Principal investigator
First posted
Sep 30, 2015
Start date
Sep 2015
Primary completion
Dec 2016
Completion
Dec 2016
Last update
Jan 25, 2022

Study contacts

IVAN J NUÑEZ GIL, MD,PhD,FESC
study chair · HOSPITAL CLINICO SAN CARLOS.

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2022. You cannot join it, but the record below documents what was studied.

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