An interventional study of CT Scan and ultrasonography in Severe Cerebral Pathology, sponsored by Centre Hospitalier Universitaire de Saint Etienne. Completed at 1 site in France. Open to participants aged 18 Years to 100 Years. Per ClinicalTrials.gov, last updated 2017-09-06.
Sponsored by Centre Hospitalier Universitaire de Saint Etienne · Not applicable, Interventional, and Diagnostic
Intensive care unit acquired muscle weakness (ICUAW) is a common disease. After 7 days of mechanical ventilation, a quarter of patients develop an ICUAW responsible of a 15-20% of muscle loss. This is a serious pathology associated with high morbidity and mortality.
Clinical diagnosis of ICUAW is difficult and need a patient awoken. CT scan and Magnetic Resonance Imaging (MRI) are considered as "gold standards" to quantify and monitor changes in muscle mass. But these tools are not adapted to ICU patients.
Ultrasound (US) is an easy access tool at the bedside to assess muscle mass and does not expose the patient to additional radiation.
The objective of this study is to evaluate the correlation between US and CT scan to measure quadriceps muscle thickness of ICU patients.
As part of the monitoring of the neurological disease, brain CT scans are frequently performed. At the same time, an acquisition sequence centered on the quadriceps will follow the brain sequences. Up to three brain CT scans coupled with a quadriceps imaging will be performed between the day of admission and on the tenth day of hospitalization. An ultrasound of the quadriceps will be performed concomitantly. The thickness of the quadriceps is measured by an independent operator on CT and ultrasound images.
494 studies on the registry are indexed under Muscular Atrophy; 94 are open to participants now.
This study's enrollment of 42 is above the median of 33 across 335 interventional studies indexed under Muscular Atrophy.
Browse Muscular Atrophy studies →Centre Hospitalier Universitaire de Saint Etienne is the lead sponsor of 578 studies on the registry; 128 are open to participants now.
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Exclusion Criteria:
Up to three measurements (CT scan and Ultrasonography), will be made concurrently between the day of admission (D1) in intensive care unit and the tenth day ( D10 ) .
Device: CT Scan and ultrasonography
Up to three measurements (CT scan and Ultrasonography) of the thickness of quadriceps, will be made concurrently .
Concordance of the measurement of the quadriceps thickness by ultrasound and by CT scan
Concordance of each of the three measurements of the thickness of quadriceps realised concurrently by CT scan and Ultrasonography (composite measure)
Time frame: Between the day of admission (D1) in intensive care unit and the tenth day ( D10 )
kinetic of the thickness of quadriceps
Evolution of he thickness of quadriceps measure concurrently by CT scan and Ultrasonography
Time frame: Between the day of admission (D1) in intensive care unit and the tenth day ( D10 )
Plan to share: No
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This study is completed, as verified in Sep 2017. You cannot join it, but the record below documents what was studied.
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Centre Hospitalier Universitaire de Saint Etienne