Changing the Vulnerable Brain: A Neuromodulation Study in Alcohol Dependence

Browse trials for

• Alcoholism 1,606

Keywords

• Repetitive Transcranial Magnetic Stimulation
• Emotion Regulation
• Craving

Alcoholism

1,606 studies on the registry are indexed under Alcoholism; 329 are open to participants now.

This study's enrollment of 80 is close to the median of 87 across 1,371 interventional studies indexed under Alcoholism.

Lead sponsor

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) is the lead sponsor of 512 studies on the registry; 178 are open to participants now.

Study arms

• Experimental
  Active Repetitive Transcranial Magnetic Stimulation (rTMS)

  Repetitive Transcranial Magnetic Stimulation: Active 10hz stimulation over the right dorsolateral Prefrontal Cortex (dlPFC)

  Device: Repetitive Transcranial Magnetic Stimulation

• Sham comparator
  Sham stimulation

  Repetitive Transcranial Magnetic Stimulation: sham stimulation over the right dlPFC

  Device: Repetitive Transcranial Magnetic Stimulation

Interventions

• DeviceRepetitive Transcranial Magnetic Stimulation

  Repetitive 10Hz right DLPFC stimulation using Magstim TMS apparatus

Primary outcomes

1. Change in BOLD response during an emotion regulation task (fMRI)

   BOLD response was measured during an emotion regulation task. The change in BOLD response between sessions is the primary outcome for this study

   Time frame: Change in BOLD response from baseline, compared to BOLD response after stimulation (approximately two weeks later)

Secondary outcomes

1. Change in experienced emotion during an emotion regulation task with Visual Analogue Scales (VAS)

   Participants were instructed to either 'attend' or 'regulate' their emotion associated with the presented (negatively valenced) pictures. Experienced (or regulated) emotion was assessed with visual analogue scales (VAS).

   Time frame: Change in experienced emotion from baseline, and after the stimulation session (approximately two weeks later)

2. Change in craving levels [Alcohol Urge Questionnaire (AUQ)]

   The AUQ was administered in order to assess craving levels. The AUQ consists of eight statements wich are rated on a 7 point likert scale \[0 = Strongly disagree, 6 = Strongly Agree\]

   Time frame: Before and after the emotion regulation task, during both baseline and stimulation session (e.g. 4 time points, sessions were separated by approximately two weeks)

Publications

• Jansen JM, van Holst RJ, van den Brink W, Veltman DJ, Caan MW, Goudriaan AE. Brain function during cognitive flexibility and white matter integrity in alcohol-dependent patients, problematic drinkers and healthy controls. Addict Biol. 2015 Sep;20(5):979-89. doi: 10.1111/adb.12199. Epub 2014 Dec 5. PubMed 25477246 ↗
• Jansen JM, Daams JG, Koeter MW, Veltman DJ, van den Brink W, Goudriaan AE. Effects of non-invasive neurostimulation on craving: a meta-analysis. Neurosci Biobehav Rev. 2013 Dec;37(10 Pt 2):2472-80. doi: 10.1016/j.neubiorev.2013.07.009. Epub 2013 Jul 31. PubMed 23916527 ↗
• Jansen JM, van den Heuvel OA, van der Werf YD, de Wit SJ, Veltman DJ, van den Brink W, Goudriaan AE. The Effect of High-Frequency Repetitive Transcranial Magnetic Stimulation on Emotion Processing, Reappraisal, and Craving in Alcohol Use Disorder Patients and Healthy Controls: A Functional Magnetic Resonance Imaging Study. Front Psychiatry. 2019 May 7;10:272. doi: 10.3389/fpsyt.2019.00272. eCollection 2019. PubMed 31133889 ↗
• Jansen JM, van den Heuvel OA, van der Werf YD, de Wit SJ, Veltman DJ, van den Brink W, Goudriaan AE. Emotion Processing, Reappraisal, and Craving in Alcohol Dependence: A Functional Magnetic Resonance Imaging Study. Front Psychiatry. 2019 Apr 9;10:227. doi: 10.3389/fpsyt.2019.00227. eCollection 2019. PubMed 31057439 ↗