An interventional study of T specific response for diagnostic of aspergillus bronchitis in Cystic Fibrosis Patient and Patient Without Treatment Against A.Fumigatus, sponsored by University Hospital, Montpellier. Terminated at 1 site in France. Open to participants aged 15 Years and older. Per ClinicalTrials.gov, last updated 2019-05-09.
Sponsored by University Hospital, Montpellier · Not applicable, Interventional, and Diagnostic
The study aims to asses the ability of cell tests based on the analysis of the anti-Aspergillus cell responses and identify Aspergillus bronchitis with patients with cystic fibrosis.
In addition, the study will evaluate the contribution of biological classification of aspergillosis according to criteria recently proposed by Baxter et al. compared to the classification used in clinical practice in the hospital of Montpellier.
268 studies on the registry are indexed under Bronchitis; 26 are open to participants now.
This study's enrollment of 68 is below the median of 120 across 184 interventional studies indexed under Bronchitis.
Browse Bronchitis studies →University Hospital, Montpellier is the lead sponsor of 1,244 studies on the registry; 225 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Other: T specific response for diagnostic of aspergillus bronchitis
Number of CD4 T cell response against Aspergillus fumigatus in patients with cystis fibrosis
Analysis T cells response for identification of aspergillus bronchitis with cystic fibrosis patients
Time frame: 12 months
Cytokine level of TCD8
Qualitative Evaluation of cytokine level (IFNg, TNFa, IL10 and IL4) of TCD8 to identify ABPA and aspergillus bronchitis
Time frame: 12 months
Cytokine level CD4 cells
Qualitative Evaluation of cytokine level CD4 cells in order to identify ABPA and aspergillus bronchitis
Time frame: 12 months
Level of fumigatus specific IgE
Contribution of several biological tests improve classification of aspergillus bronchitis
Time frame: 12 months
Level of fumigatus specific IgG
Contribution of several biological tests improve classification of aspergillus bronchitis
Time frame: 12 months
Real-time PCR for aspergillus in sputum
Contribution of several biological tests improve classification of aspergillus bronchitis
Time frame: 12 months
Galactomannan by enzyme immune assay detection in sputum
Contribution of several biological tests improve classification of aspergillus bronchitis
Time frame: 12 months
Levels of cytokine (IFNg, IL10, IL4 and TNF) evaluated by flow cytometry
Contribution of several biological tests improve classification of aspergillus bronchitis
Time frame: 12 months
Level of IL10 evaluated by Elispot dedicated to anti-aspergillus CD4 T cells
Contribution of several biological tests improve classification of aspergillus bronchitis
Time frame: 12 months
Flow cytometry techniques dedicated to anti-aspergillus CD4 T cell assessment
Time frame: 12 months
Level of IFNg evaluated by Elispot dedicated to anti-aspergillus CD4 T cells
Contribution of several biological tests improve classification of aspergillus bronchitis
Time frame: 12 months
Elispot dedicated to anti-aspergillus CD4 T cell
Time frame: 12 months
This study is terminated, as verified in Dec 2016. You cannot join it, but the record below documents what was studied.
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University Hospital, Montpellier