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Status unknownNCT02524912Updated Nov 20, 2015

Methadone Maintenance Outcome Study in Taiwan: 5-year Follow-up

An observational study in Heroin Dependence, Sleep Impairment and Mortality, sponsored by National Health Research Institutes, Taiwan. Status unknown. Open to participants aged 20 Years and older. Per ClinicalTrials.gov, last updated 2015-11-20.

Sponsored by National Health Research Institutes, Taiwan · Observational

The sponsor has not verified this record recently (last verified Sep 2015), so the status shown — last known as Active, not recruiting — may be out of date.
Study type
Observational
Model
Cohort
Enrollment
1,200
Ages
20 Years and older
Sex
All
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Study summary

Methadone maintenance treatment (MMT) has been one of the most effective treatment choices for opioid addicts to reduce their heroin use, criminality and spread of HIV. In Taiwan, MMT has been introduced since 2006. To date, more than 30,000 opioid addicts have ever participated in MMT, but only around 10,000 retains in treatment. Outcomes of the ever-treated MMT patients remain unclear. It is crucial to trace the opioid addicts' treatment career, outcomes and unmet treatment needs for the service providers to modify treatment strategy to help these individual to maintain abstinence. Moreover, understanding of the determinants for these subjects' long-term outcomes is important for policy makers to implement realistic policies to motivate the service providers and patients.

From the results of previous research, the research team found that early dropout, defined as stayed in-treatment less than one month, of MMT participants were 14.4%. The rate of maintaining in treatment at 3rd , 6th, and 12th month were 65.7%、51.3% and 33.8%, respectively. Average treatment days for 12-month is 186.9±141.2. This result showed that the effectiveness of the MMT was varied among different facilities. On the other hand, the quality of the MMT can be improved largely through different dimensions. Besides, if one participant can enhance its motivation in staying in-treatment, it could reduce 15% early dropout. Above all, the result also showed that though the quality of life was recorded as improved after MMT, it appeared to be significantly lower than their healthy counterparties. The assessments of health outcomes after participating MMT are rare, but in need. It is necessary to make some modification to improve the effectiveness. Moreover, the evaluation of the needs shall not limit to patients, but also extend to their family members.

Therefore, in this study, the research team plans to probe the dimensions from physical, psychiatric, to social conditions by assessing patients and their family members after treated by MMT for five years. The research team would like to know more about the outcomes of those who attended MMT five years ago, their physical and mental health conditions, also health status of their family members.

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Conditions studied

  • Heroin Dependence
  • Sleep Impairment
  • Mortality
  • Quality of Life
  • Treatment Outcome

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In context

Heroin Dependence

87 studies on the registry are indexed under Heroin Dependence; none are open to participants now.

This study's planned enrollment of 1,200 is above the median of 26 across 16 observational studies indexed under Heroin Dependence.

Browse Heroin Dependence studies →

Lead sponsor

National Health Research Institutes, Taiwan is the lead sponsor of 125 studies on the registry; 29 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
20 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

We included participants in this current study from those who attended our three studies before (IRB approved ID: EC0980203, EC0980209, EC1010102).

Inclusion criteria

  • Attended EC0980203, EC0980209, EC1010102 projects
  • Nationality: Taiwan
  • 20-year-old and above
  • Match the diagnosis of heroin dependence from DSM-IV
  • Able to fill out the informed consent

Exclusion criteria

Exclusion Criteria:

  • Acute major physical or mental illness (need immediate health care)
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Study design

Observational model
Cohort
Enrollment
1,200 participants (estimated)
Target follow-up
1 Year
Patient registry
Yes
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What researchers measure

Primary outcomes

  1. All cause mortality

    Time frame: Five-year

Secondary outcomes

  1. Sleep impairment via Chinese version of the Pittsburgh Sleep Quality Index

    Time frame: One month

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Study locations

No study locations are listed for this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 20, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02524912
Lead sponsor
National Health Research Institutes, Taiwan
Responsible party
Sponsor
First posted
Aug 17, 2015
Start date
Apr 2015
Primary completion
Mar 2017 (estimated)
Completion
Mar 2017 (estimated)
Last update
Nov 20, 2015
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Sep 2015. You cannot join it, but the record below documents what was studied.

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