An interventional study of Metformin and Magnesium in Polycystic Ovary Syndrome and Obesity, sponsored by Coordinación de Investigación en Salud, Mexico. Terminated at 1 site in Mexico. Open to female participants aged 18 Years to 38 Years. Per ClinicalTrials.gov, last updated 2025-04-01.
Sponsored by Coordinación de Investigación en Salud, Mexico · Not applicable, Interventional, and Treatment
Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in reproductive age women. PCOS is usually characterized by an excessive androgen production, menstrual irregularities, and polycystic ovaries. Women with PCOS are often obese and have a varying degree of insulin resistance (IR). Weight reduction constitutes the initial treatment for these patients. Metformin has proven to be useful in IR and is frequently used in PCOS. However metformin use may be accompanied by gastrointestinal discomfort, and a high abandon rate. Other therapeutic alternatives such as magnesium and polyunsaturated fatty acids have been used in other IR states and may be useful in PCOS. The aim of this study is to asses the efficacy of these alternatives in obese PCOS patients.
Polycystic Ovary Syndrome (PCOS)
944 studies on the registry are indexed under Polycystic Ovary Syndrome; 174 are open to participants now.
This study's enrollment of 123 is above the median of 70 across 685 interventional studies indexed under Polycystic Ovary Syndrome.
Browse Polycystic Ovary Syndrome studies →Coordinación de Investigación en Salud, Mexico is the lead sponsor of 95 studies on the registry; 17 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Metformin 850mg twice a day for six months
Drug: Metformin
Magnesium chloride 250mg daily for six months
Dietary Supplement: Magnesium
Eicosapentaenoic acid (EPA) + Docosahexaenoic acid (DHA) 1.1mg daily for six months
Dietary Supplement: PUFA
Intervention also includes weight reduction diet and exercise therapy
Also known as: Glucophage
Intervention also includes weight reduction diet and exercise therapy
Also known as: Nature made magnesium
Intervention also includes weight reduction diet and exercise therapy
Also known as: Omega 3
Metabolic profile
Serum concentration of metabolic biomarkers (glucose, insulin, triglycerides, cholesterol, HDL, M and M/I value derived from a euglycemic clamp)
Time frame: Six months after intervention
Hormonal profile
Serum concentration of hormones \[Testosterone, dehydroepiandrosterone sulphate (DHEAs), sex hormone-binding globulin (SHBG), free androgen index (FAI)\]
Time frame: Six months after intervention
Plan to share: No — There is not a plan to share data
No publications or documents are linked to this record.
This study is terminated, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.
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Coordinación de Investigación en Salud, Mexico