An observational study in Cardiac Arrest, sponsored by Hopital of Melun. Completed. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2015-07-31.
Sponsored by Hopital of Melun · Observational
Early prognostication in resuscitated cardiac arrest (CA) patients, within the first day after admission in the intensive care unit (ICU), remains difficult. Optic nerve sheath diameter (ONSD) measurement could predict increased intracranial pressure. Preliminary works showed that ONSD measurement could be used to predict outcome in post-CA patients.
The aim of this study was to assess the ability of bedside ONSD ultrasonographic measurement to predict survival and Cerebral Performance Category (CPC) score at hospital discharge in post-cardiac arrest patients treated with therapeutic hypothermia (TH).
Prospective observational study including all consecutive successfully resuscitated and TH-treated CA patients without traumatic or neurological etiology of CA in two French ICUs. ONSD measurements were performed on day 1, 2, and 3 after return of spontaneous circulation (ONSD1,2,3 respectively).
The primary outcome is survival at hospital discharge (with an average follow-up of 3 month until ICU admission).
984 studies on the registry are indexed under Heart Arrest; 227 are open to participants now.
This study's enrollment of 36 is below the median of 196 across 394 observational studies indexed under Heart Arrest.
Browse Heart Arrest studies →Hopital of Melun is the lead sponsor of 8 studies on the registry; none are open to participants now.
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All unconscious (Glasgow Coma Scale ≤6) patients ≥18 years old, admitted in ICU after successful resuscitation from CA, and treated with TH targeted to 33°C were screened. Exclusion criteria were as follows: unavailable ONSD measurement within 24 hours after return of spontaneous circulation (unavailable investigator, early death, or major hemodynamic instability), traumatic or neurological origin of CA, previous cerebrovascular disease, facial trauma affecting the orbits and/or eyeballs, and previous history of ocular pathology such as exophthalmia, glaucoma or cataract.
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Exclusion Criteria:
In-hospital mortality
participants will be followed for the duration of hospital stay, an expected average of 3 months.
Time frame: 3 months
No study locations are listed for this record.
This study is completed, as verified in Jul 2015. You cannot join it, but the record below documents what was studied.
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Hopital of Melun