A Phase 4 interventional study of healthy lifestyle and Metformin in Insulin Resistance, sponsored by Beijing Tsinghua Chang Gung Hospital. Status unknown at 1 site in China. Open to participants aged 20 Years to 35 Years. Per ClinicalTrials.gov, last updated 2016-07-21.
Sponsored by Beijing Tsinghua Chang Gung Hospital · Phase 4, Interventional, and Prevention
This research would take medical interventions in subjects of insulin resistance without abnormal glucose tolerance, to see if there were different prevalence of abnormal glucose tolerance in different groups.
The situation of type 2 DM prevention in China is serious. The commonly accepted natural course of type 2 DM is as follows: obesity, insulin resistance(hyperinsulemia), abnormal glucose tolerance, DM and complications of DM; correspondently, the function status of pancreas islet β cells are: normal, compensatory, decompensatory, impaired and failure. Post researches have proved that using medical interventions after the period of insulin resistance when the function status of β cells were compensatory, the course could not be reversed. There were few clinical researches about effects of medical interventions in the period of insulin resistance . This research would take medical interventions in subjects of insulin resistance without abnormal glucose tolerance, to see if there were different prevalence of abnormal glucose tolerance in different groups.
1,960 studies on the registry are indexed under Insulin Resistance; 306 are open to participants now.
This study's planned enrollment of 60 is above the median of 40 across 1,536 interventional studies indexed under Insulin Resistance.
Browse Insulin Resistance studies →Beijing Tsinghua Chang Gung Hospital is the lead sponsor of 96 studies on the registry; 52 are open to participants now.
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Exclusion Criteria:
subjects in this group will accept healthy lifestyle changes such as food control and intensive exercise for 3 months first. Then their insulin resistance will be evaluated again . If their insulin resistance didn't improve, then they will take metformin 0.5g qd to reduce insulin resistance. If their insulin resistance improved, they will continued healthy lifestyle changes.
Behavioral: healthy lifestyle · Drug: Metformin
subjects in this group will not accept medical interventions
food control and intensive exercise to lose weight
use metformin to reduce insulin resistance
prevalence of abnormal glucose intolerance
OGTT test will be took in these subjects to find out if their glucose tolerance was abnormal
Time frame: two years after the subject joins the research
This study is status unknown, as verified in Jul 2016. You cannot join it, but the record below documents what was studied.
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Beijing Tsinghua Chang Gung Hospital