An observational study in Valvular Heart Disease, sponsored by Yonsei University. Completed at 1 site in Korea, Republic of. Open to participants aged 20 Years and older. Per ClinicalTrials.gov, last updated 2019-01-29.
Sponsored by Yonsei University · Observational
One of the most important factor that affects the post op complication of the cardiac surgery is systemic inflammation. Valvular heart surgery requires cardiopulmonary bypass and cardioplegic arrest, which can arouse the ischemic/reperfusion injury causing myocardial damage and inflammatory response. These myocardial damage and inflammatory response can cause multi-organ failure or even death.
One of the most important factor that affects the post op complication of the cardiac surgery is systemic inflammation. Valvular heart surgery requires cardiopulmonary bypass and cardioplegic arrest, which can arouse the ischemic/reperfusion injury causing myocardial damage and inflammatory response. These myocardial damage and inflammatory response can cause multi-organ failure or even death.
High-mobility group protein B1 (HMGB1) is a protein which is encoded by the HMGB1 gene in human. HMGB1 is secreted by immune cells (like macrophages, monocytes and dendritic cells). Activated macrophages and monocytes secrete HMGB1 as a cytokine mediator of Inflammation. There are many studies suggesting the relationship between HMGB1 and acute coronary syndrome, myocardial ischemic/reperfusion injury, atherosclerosis, heart failure and other cardiac disease as a marker for inflammatory response. However, there are no other study evaluating HMGB1 as a prognostic factor after valvular surgery, so far.
3,640 studies on the registry are indexed under Heart Diseases; 461 are open to participants now.
This study's enrollment of 250 is below the median of 294 across 1,241 observational studies indexed under Heart Diseases.
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people who undergo valvular heart surgery
Exclusion Criteria:
Evaluation of the high mobility group box 1 as a prognostic biomarker in patients undergoing valvular heart surgery
Procedure: Blood sampling
Blood sampling 5ml
concentration of HMGB1
The relationship between concentration of HMGB1 and post op prognosis in patients undergoing valvular heart surgery
Time frame: collect blood sample right before the surgery after induction of anesthesia
This study is completed, as verified in Jan 2019. You cannot join it, but the record below documents what was studied.
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Yonsei University