An interventional study of Bag-mask ventilation and Noninvasive positive pressure ventilation(NIPPV) in Respiratory Failure, sponsored by Lingbo Nong. Completed at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-08-04.
Sponsored by Lingbo Nong · Not applicable, Interventional, and Treatment
This study is to investigate the efficiency and safety of fibreoptic bronchoscopy assisted intubation during noninvasive positive pressure ventilation in respiratory failure patients. Half of the participants will receive preoxygenation with noninvasive ventilator and fibreoptic bronchoscopy intubation during NIPPV. While the other half using usual preoxygenation(bag-mask ventilation ).
Respiratory failure is very common for critically ill patients, Main complication associated with intubation was desaturation. Usual preoxygenation( bag-mask ventilation) have been show that marginally effective in critically ill patients. As a result, there is a need to optimize the technique of preoxygenation to prolong the safe duration of apnea during the intubation procedure in critically ill patients. Noninvasive ventilation provides continuous positive airway pressure is effective in increasing the efficiency of gas exchange and in reducing the decrease in oxyhemoglobin saturation during fiberoptic bronchoscopy in hypoxemic patients.
Therefore, our aim was to study whether NIPPV is more effective at reducing desaturation than usual preoxygenation in hypoxemic, critically ill patients requiring intubation in ICU.
1,650 studies on the registry are indexed under Respiratory Insufficiency; 296 are open to participants now.
This study's enrollment of 106 is above the median of 55 across 1,043 interventional studies indexed under Respiratory Insufficiency.
Browse Respiratory Insufficiency studies →This is the only study on the registry with Lingbo Nong as lead sponsor.
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Exclusion Criteria:
Preoxygenation with Bag-mask ventilation before fibreoptic bronchoscopy assisted intubation. Intervention: Bag-mask ventilation.
Procedure: Bag-mask ventilation · Procedure: fibreoptic bronchoscopy assisted intubation
The NIPPV group preoxygenation with noninvasive positive pressure ventilation(NIPPV), And then receives fibreoptic bronchoscopy intubation through a face mask (there is a small hole allow to insert the tracheal tube through the mask into trachea) during NIPPV. Intervention: noninvasive positive pressure ventilation(NIPPV)
Procedure: Noninvasive positive pressure ventilation(NIPPV) · Procedure: fibreoptic bronchoscopy assisted intubation
The control group receives preoxygenation with bag-mask ventilation
The NIPPV group receives noninvasive positive pressure ventilation during fibreoptic bronchoscopy assisted intubation
All patients will receive fibreoptic bronchoscopy assisted intubation.
Change in pulse oxymetry(SpO2)
Time frame: From time of randomization until connect to ventilator 30min
Mechanical ventilation Time
Time frame: 28 days
28 days survival rate
Time frame: From the day of intubation to 28 days
This study is completed, as verified in Aug 2017. You cannot join it, but the record below documents what was studied.
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