An interventional study of Expiratory muscle strength training (EMST) and Transcranial magnetic stimulation (TMS) in Parkinson's Disease, sponsored by University Hospital Muenster. Completed at 1 site in Germany. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2018-09-24.
Sponsored by University Hospital Muenster · Not applicable, Interventional, and Treatment
The purpose of the study is to examine the effectiveness of different methods for the treatment of dysphagia in Parkinson's disease (PD). More than 80% of patients suffering from PD develop dysphagia during the course of their disease leading to malnutrition, loss of life quality, weight loss and pneumonia, which is the leading cause of death in these patients. So far, only a few specific treatment approaches have been investigated in PD patients with swallowing disorders. The investigator want to compare a 4-week expiratory muscle strength training (EMST), transcranial magnetic stimulation (TMS), and combination of both with a sham therapy. Dysphagia severity before and after intervention is measured by flexible endoscopic evaluation of swallowing (FEES). For the evaluation of changes in cortical swallowing processing the investigators apply magnetoencephalography (MEG).
4,487 studies on the registry are indexed under Parkinson Disease; 1,082 are open to participants now.
This study's enrollment of 53 is above the median of 40 across 3,294 interventional studies indexed under Parkinson Disease.
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Active expiratory muscle strength training in combination with sham transcranial magnetic stimulation
Device: Expiratory muscle strength training (EMST) · Other: Transcranial magnetic stimulation (TMS)
Sham expiratory muscle strength training in combination with active transcranial magnetic stimulation
Device: Expiratory muscle strength training (EMST) · Other: Transcranial magnetic stimulation (TMS)
Active expiratory muscle strength training in combination with active transcranial magnetic stimulation
Device: Expiratory muscle strength training (EMST) · Other: Transcranial magnetic stimulation (TMS)
Sham expiratory muscle strength training in combination with sham transcranial magnetic stimulation
Device: Expiratory muscle strength training (EMST) · Other: Transcranial magnetic stimulation (TMS)
The EMST is performed 4 weeks, 5 days per week, for 20 minutes per day, using a calibrated or sham, handheld device (EMST 150, Aspire Products, Gainesville, FL).
A sham or active transcranial magnetic stimulation is performed at the last 5 days of EMST training.
Dysphagia severity as measured by FEES
Time frame: Four weeks
Cortical reorganization of swallowing process as detected by MEG
Time frame: Four weeks and three month
Changes in quality of life as measured by the swallowing quality of life questionnaire (Swal-Qol)
Time frame: Four weeks and three months
Dysphagia severity as measured by FEES
Time frame: Three month
This study is completed, as verified in Oct 2017. You cannot join it, but the record below documents what was studied.
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University Hospital Muenster