An observational study in Human Herpes Virus, Herpes Simplex Virus and Varicella-zoster Virus, sponsored by The University of Texas Medical Branch, Galveston. Completed. Per ClinicalTrials.gov, last updated 2015-05-22.
Sponsored by The University of Texas Medical Branch, Galveston · Observational
Herpes simplex virus, cytomegalovirus and varicella zoster virus infection are purported to play a pivotal role in morbidity and mortality in burns. Thus far, there is no existing systematic review (Level of Evidence III or higher) describing the unique role as well as concurrent infections of these viruses in burns. The aim of this review is to point out the clinical differences between these human herpes virus subtypes, to outline established therapy approaches, and to provide evidence for virus related morbidity and mortality in burns.
This systematic review was created according the PRIMSA (preferred reporting items for systematic reviews and meta-analyses) guidelines and checklist.
We performed an review of the medical literature to identify all studies that contain HSV, CMV and VZV infections in burns.Therefore, systematic review of the Medline database by using PubMed and Ovid interface was conducted. Also the Web of Science interface was used for systematic literature search.
On the PubMed interface, we used the following search terms: ("HSV"[All Fields] OR "herpes"[All Fields] OR "CMV"[All Fields] OR "cytomegalovirus"[All Fields] OR "VZV"[All Fields] OR "varicella-zoster"[All Fields]) AND ("burns"[MeSH Terms] OR "burns"[All Fields] OR "burn"[All Fields] OR "thermal trauma"[All Fields]). For Ovid we used: exp Burns/ AND (exp Herpes Zoster/ or exp Encephalitis, Herpes Simplex/ or exp Herpes Simplex/ or exp Herpes Simples Virus Vaccines/), exp Burns/ AND (exp Cytomegalovirus/ or exp Cytomegalovirus Infections/), exp Burns/ AND (exp Chickenpox/ or Herpesvirus 3. Human/ or exp Herpes Zoster/). And for Web of Science we used: (TS=(HSV OR herpes OR CMV OR cytomegalovirus OR VZV OR varicella-zoster) AND TS=(burn OR burns OR thermal trauma)) AND LANGUAGE: (English) AND DOCUMENT TYPES: (Article); Timespan: All years; Indexes: SCI-EXPANDED, SSCI, A\&HCI, CPCI-S.
914 studies on the registry are indexed under Virus Diseases; 110 are open to participants now.
This study's enrollment of 10,267 is above the median of 300 across 275 observational studies indexed under Virus Diseases.
Browse Virus Diseases studies →The University of Texas Medical Branch, Galveston is the lead sponsor of 251 studies on the registry; 38 are open to participants now.
Of its 30 completed or terminated interventional studies of FDA-regulated products, 25 (83%) have results posted.
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Every year, about 500,000 citizens of the United States of America were burned; 50,000 of them were admitted to Burn Center. Bacterial and viral infections including cellulitis, pneumonia, wound infections and septicemia are among the top ten complications of burn injuries. Severe burn injury causes an increased inflammatory response and an overall immunosuppression. As a result severely burned patients are more prone to infections and septicemia. Early treatment of sepsis and prevention of infections are key to reducing morbidity and improving the long-term outcome of burn victims.
Exclusion Criteria:
The included patient are burn victims who sustained a burn of at least 1 % total body surface are (TBSA); with no restriction on age.
Other: Review of the Literature for Human Herpes Virus infections
Review of the Medline database (PubMed and Ovid interface) for human herpes virus infections in burns as well as Web of Science interface. PRIMSA (preferred reporting items for systematic reviews and meta-analyses) guidelines and checklist were used.
Prevalence of Human Herpes Virus (HHV) Infections
HHV include the herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr viruses (EBV) and human herpes virus 6 to 8
Time frame: Participants will be followed for the duration of hospital stay, an expected average of 3 months.
Treatment of Human Herpes Virus (HHV) Infections
Time frame: Participants will be followed for the duration of hospital stay, an expected average of 3 months.
No study locations are listed for this record.
This study is completed, as verified in May 2015. You cannot join it, but the record below documents what was studied.
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The University of Texas Medical Branch, Galveston