An interventional study of sodium lactate Ringer's injection(Baxter, ShangHai, China) and Compound Sodium Chloride Injection (CR Double-Crane, Beijing, China) in Severe Sepsis With Septic Shock and Lactate, sponsored by Peking Union Medical College Hospital. Status unknown. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2015-05-20.
Sponsored by Peking Union Medical College Hospital · Not applicable, Interventional, and Treatment
Using sodium lactate Ringer's injection resuscitate septic shock patients and Compared with other solution, in order to make clear whether can improve the prognosis.
Experimental evidence repeatedly demonstrated that the shock patients can use substrates other than glucose to sustain increased activity, including lactate.Increased lactate can be the consequence of anaerobic metabolism, i.e., the formation of lactate in the presence of low oxygen. However, emerging evidence demonstrated that in patients with sepsis increased lactate seems predominantly non-hypoxic/ischemic and rather the consequence of increased glycolysis. Utilization of lactate as an alternative fuel may be an adaptive response to maximize energy function and limit substrate reduction.Uptake of exogenous lactate has indeed been demonstrated after traumatic brain injury and acute heart failure in humans.
The investigators assume that administration of supplemental lactate significantly contributes to energy metabolism in septic shock, which can have beneficial help for septic shock resuscitation.
Inclusion criteria:diagnosis in patients with septic shock and age 18 years old or more. Exclusion criteria: pregnant women and nursing mothers, severe liver failure with child class C , use linezolid anti-infection treatment, pheochromocytoma patients, CVVH therapy patients, malignant tumor patients, using epinephrine.
The investigators will use sodium lactate Ringer's injection resuscitate septic shock patients and Compared with other solution, the organ function monitoring include heart, kidney,and brain. Others study endpoints include 28-day mortality,hospitalized mortality.
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Exclusion Criteria:
Drug: sodium lactate Ringer's injection(Baxter, ShangHai, China)
Drug: Compound Sodium Chloride Injection (CR Double-Crane, Beijing, China)
use sodium lactate Ringer's injection to resuscitate the septic shock patients(lactate group)
use Compound Sodium Chloride injection to resuscitate the septic shock patients(control group)
28-day mortality
Time frame: 28 days after the diagnosis of septic shock
No study locations are listed for this record.
The record gives a start of Sep 2015, a primary completion of Dec 2016 and a completion of Dec 2016. It does not say whether these dates are actual or estimated.
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This study is status unknown, as verified in May 2015. You cannot join it, but the record below documents what was studied.
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