An interventional study of continuous venovenous hemofiltration and Control group in Hypernatremia and Critically Ill, sponsored by Air Force Military Medical University, China. Status unknown at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2015-07-13.
Sponsored by Air Force Military Medical University, China · Not applicable, Interventional, and Treatment
The patients with severe hypernatremia who received conventional treatment are often undertreated. Continuous venovenous hemofiltration (CVVH) can effectively remove solute or water from circulation system. Several case reports demonstrated that CVVH could effectively decrease serum sodium concentration of the patients with severe hypernatremia. The use of CVVH for acute severe hypernatremia in critically ill patients could improve patient survival by effectively decreasing the serum sodium concentration to a normal level.
Date collection:
8.Daily sodium intake 9.Adverse events were confirmed 10.Laboratory date: Routine blood test Blood biochemical Blood gas analysis Blood electrolyte Plasma osmotic pressure Urine osmotic pressure Plasma osmotic pressure Urinary electrolyte excretion fraction
49 studies on the registry are indexed under Hypernatremia; 8 are open to participants now.
This study's planned enrollment of 60 is close to the median of 64 across 32 interventional studies indexed under Hypernatremia.
Browse Hypernatremia studies →Air Force Military Medical University, China is the lead sponsor of 178 studies on the registry; 37 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The human immunodeficiency virus, which weakens the immune system.
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HIV
The human immunodeficiency virus, which weakens the immune system.
Many studies now accept people whose HIV is controlled on treatment, judged by the viral load and the CD4 count. Check the limits this study sets.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
CVVH was mainly determined by the differences of sodium concentration between serum and replacement fluid. The rate of decline serum sodium could be real-time adjusted using different-sodium-concentration replacement fluid according to the updated serum sodium concentration.
Procedure: continuous venovenous hemofiltration
Treatment of hypernatremia is correction of water deficit.
Drug: Control group
If the serum sodium concentration \>150mmol/L, When filter occurred clotting, replace the filter to CVVH treatment
Also known as: continuous renal replacement therapy
If the serum sodium concentration ≤150mmol/L, When filter occurred clotting, as the end of treatment.
Also known as: standard treatments
7-day all cause mortality
Time frame: 7days
Glasgow Coma score changes
On the third day of the Glasgow Coma score minus baseline of the Glasgow Coma score
Time frame: 3 days
Sequential Organ Failure Assessment score changes
On the third day of the Sequential Organ Failure Assessment score minus baseline of the Sequential Organ Failure Assessment score
Time frame: 3 days
Acute Physiology and Chronic Health Evaluation II score changes
On the third day of the Acute Physiology and Chronic Health Evaluation II score minus baseline of the Acute Physiology and Chronic Health Evaluation II score
Time frame: 3 days
The average reduce rate of serum sodium
The average reduce rate of serum sodium was calculated as following: (serum sodium concentration before treatment (mmol/L) - serum sodium concentration after treatment (mmol/L)) / time after treatment (hours)
Time frame: 3 days
24-hour correction of hypernatremia
Twenty-four-hour correction of hypernatremia was defined as the reduction of serum sodium concentration to ≤145 mmol/L within 24 hours after the start of treatment.
Time frame: 24-hour
The record gives a start of Jun 2015, a primary completion of Jun 2017 and a completion of Jun 2017. It does not say whether these dates are actual or estimated.
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This study is status unknown, as verified in Jul 2015. You cannot join it, but the record below documents what was studied.
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Air Force Military Medical University, China →