An interventional study of Furcation treatment with PRF and Furcation Treatment with Allograft and GTR in Chronic Periodontitis, sponsored by Dr.Syed Asimuddin. Completed. Open to participants aged 30 Years to 50 Years. Per ClinicalTrials.gov, last updated 2017-04-07.
Sponsored by Dr.Syed Asimuddin · Not applicable, Interventional, and Treatment
Background: Furcation is the bifurcation or trifurcation of a multirooted tooth. It is an area of complex anatomic morphology difficult to debride by routine periodontal instrumentation. Multiple approaches have been used in an effort to treat the furcation Choukroun's platelet-rich fibrin (PRF), a second generation platelet concentrate has biochemical components which have well known synergetic effects on healing processes. The present study was conducted to evaluate the effectiveness of autologous platelet-rich fibrin (PRF) in the treatment of mandibular molar Grade 2 furcation defects in comparison to allograft and guided tissue regeneration (GTR) membrane.
ABSTRACT Background: Furcation is the bifurcation or trifurcation of a multirooted tooth. It is an area of complex anatomic morphology difficult to debride by routine periodontal instrumentation. Multiple approaches have been used in an effort to treat the furcation Choukroun's platelet-rich fibrin (PRF), a second generation platelet concentrate has biochemical components which have well known synergetic effects on healing processes. The present study was conducted to evaluate the effectiveness of autologous platelet-rich fibrin (PRF) in the treatment of mandibular molar Grade 2 furcation defects in comparison to allograft and guided tissue regeneration (GTR) membrane. MATERIALS AND METHODS: The study was designed as a randomized, prospective, parallel-arm, interventional clinical trial wherein 30 patients with periodontitis and grade II Mandibular furcation defects attending the Out Patient wing of the Department of Periodontics of a tertiary referral care hospital were equally divided into group A and group B. Patients in.Group A, were treated by the placement of PRF as a Graft and as a membrane at the surgical site , while in Group B, the defects were treated by the placement of Allograft and Healiguide collagen membrane. Plaque Index, Probing depth, Vertical clinical attachment level, Horizontal clinical attachment level, Gingival marginal level, and amount of bonefill using Radiovisiography were recorded at baseline and 9 months. Intra-group comparison of Mean scores between Group A and Group B was done using Paired t test and Inter-group comparison using independent sample t test. CONCLUSION Further studies evaluating the efficacy of PRF using a larger sample size should be performed to evaluate its true beneficial effects on long term basis in patients with mandibular molar Grade 2 furcation defects.
Exclusion Criteria:
Group A- Furcation Treatment with PRF
Procedure: Furcation treatment with PRF · Device: autologous platelet-rich fibrin
Group B- Furcation Treatment with Allograft and GTR
Procedure: Furcation Treatment with Allograft and GTR · Device: allograft and guided tissue regeneration (GTR) membrane (DFDBM and Healiguide)
PRF Placed into the furcation after flap elevation and debridement
Also known as: Furcation Management with Platelet rich fibrin
Allograft and GTR placed into furcation after flap elevation and debridement
Also known as: Furcation Management with DFDBM and Healiguide
Vertical clinical attacment level
The Vertical clinical attachment level was assessed preoperatively and 9 months after surgery
Time frame: 9 months Post treatment
Horizontal clinical attachment level
The horizontal clinical attachment level was assessed preoperatively and 9 months after surgery.
Time frame: 9 months Post treatment
Bone fill
Bone fill was assessed radiographically and 9 months after surgery
Time frame: 9 months Post treatment
Plaque Index
Plaque index was assessed preoperatively and 9 months after surgery
Time frame: 9 Months Post treatment
Probing depth
Probing depth was assessed preoperatively and 9 months after surgery
Time frame: 9 Months Post treatment
Gingival marginal level
Gingival marginal level was assessed preoperatively and 9 months after surgery
Time frame: 9 months post treatment
No study locations are listed for this record.
Plan to share: No
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