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CompletedNCT02424214Updated Feb 19, 2018

Artificial Oocyte Activation Comparing Tow Different Agents

An interventional study of Artificial Oocyte activation and Ca Ionophore in Oocyte Fertilization, sponsored by Ibn Sina Hospital. Completed at 3 sites in 2 countries. Open to female participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-02-19.

Sponsored by Ibn Sina Hospital · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
450
Allocation
Randomized
Ages
18 Years to 40 Years
Sex
Female
01

Study summary

Comparing the efficacy of tow factors for artificial Oocyte Activation for poor quality Oocytes and Teratozoospermia patients.

Read the detailed description

The IVF outcome had been varied widely with a good portion of total fertilization failure even after the most advanced procedure for this group of patient Intracytoplasmic Sperm Injection, many factors that had been tested for assisting the failed group of patient to be fertilized artificially like Ca Ionophore, Strontium Chloride and others but we decide to compare the clinically proven factors for the efficacy and safety in a well randomized clinical trial and monitor the embryogenesis and pregnancy within the 2 groups.

02

Conditions studied

  • Oocyte Fertilization
03

In context

Lead sponsor

Ibn Sina Hospital is the lead sponsor of 28 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 40 Years
Sexes eligible
Female
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • previous fertilization failure
  • poor quality Oocytes
  • poor sperms

Exclusion criteria

Exclusion Criteria:

  • normal patients
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
450 participants (actual)

Study arms

  • Experimental
    Ca Ionophore group

    Artificial Oocyte activation with Ca Ionophore for 20 min after Intracytoplasmic Sperm Injection

    Other: Artificial Oocyte activation · Drug: Ca Ionophore

  • Experimental
    Strontium Chloride group

    Artificial Oocyte activation with Strontium Chloride for 60 min after Intracytoplasmic Sperm Injection

    Other: Artificial Oocyte activation · Drug: Strontium Chloride

  • No intervention
    Only Intracytoplasmic Sperm Injection

    after Intracytoplasmic Sperm Injection Oocytes will cultured and incubated

Interventions

06

What researchers measure

Primary outcomes

  1. Pregnancy rate ( % )

    Time frame: 9 months

Secondary outcomes

  1. Blastocyst rate ( % )

    Time frame: 9 months

07

Study locations

3 sites
  • Al Barka fertility center
    Manama, Bahrain
  • Banon Fertility Center
    Assiut, Egypt
  • Ibnsina IVF center
    Sohag, Egypt
08

References and documents

Publications

  • Fawzy M, Emad M, Mahran A, Sabry M, Fetih AN, Abdelghafar H, Rasheed S. Artificial oocyte activation with SrCl2 or calcimycin after ICSI improves clinical and embryological outcomes compared with ICSI alone: results of a randomized clinical trial. Hum Reprod. 2018 Sep 1;33(9):1636-1644. doi: 10.1093/humrep/dey258. PubMed 30099496 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 19, 2018, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02424214
Lead sponsor
Ibn Sina Hospital
Collaborators
Al Baraka Fertility Hospital, Banon IVF Center Assiut, Egypt
Responsible party
Muhammad Fawzy (IVF Lab Director, Ibn Sina Hospital) — Principal investigator
First posted
Apr 22, 2015
Start date
Apr 2015
Primary completion
Jan 2016
Completion
Jan 2016
Last update
Feb 19, 2018

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Feb 2018. You cannot join it, but the record below documents what was studied.

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Studies of the drug tested here: Strontium chloride

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