An interventional study of Oocyte double chemical activation in Infertility, sponsored by Ibn Sina Hospital. Completed at 3 sites in 2 countries. Open to female participants aged 18 Years to 44 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-09-27.
Sponsored by Ibn Sina Hospital · Not applicable, Interventional, and Supportive care
Novel approach for Oocyte fertilization failure for difficult cases not respond to traditional methods of assisted reproduction as intracytoplasmic sperm injection.
In some cases undergoes assisted reproduction technique specially Intracytoplasmic sperm injection, in subgroup of patient they fail to fertilize or poorly fertilized, some authors recommend chemical activation for those group of patient with Ca ionophore but still with Ca ionophore there are some cases with total fertilization failure or low fertilization specially in those patient with 2 separate factors like teratozoospermia with poor quality Oocytes so the investigators decided to test the effect of double activation methods by using tow agents proven with life birth rate Ca ionophore and strontium chloride.
We Do intracytoplasmic sperm injection and immediately activate oocyte with Ca Ionophore followed by strontium chloride activation and monitoring the embryogenesis until the blastocyst formation and pregnancy outcome in multicenter assessment.
Exclusion Criteria:
The Oocytes in this arm will undergo double activation with Ca ionophore 5 micro mol for 20 min them Strontium chloride 10 micro mol for 60 min.
Other: Oocyte double chemical activation
The Oocytes will undergo Intracytoplasmic sperm injection only
Oocyte double chemical activation
Clinical Pregnancy rate ( % )
To predict percentage of pregnant women from those will undergo Embryo transfer
Time frame: 3 months
Blastocyst rate ( % )
Number of embryos will reach blastocyst stage at day 5 post Intracytoplasmic sperm injection
Time frame: 3 months
This study is completed, as verified in Sep 2018. You cannot join it, but the record below documents what was studied.
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Ibn Sina Hospital