An interventional study of aerobic exercise and combined exercise in Scoliosis and Adolescent Scoliosis, sponsored by Faculdade de Ciências Médicas da Santa Casa de São Paulo. Completed at 1 site in Brazil. Open to participants aged 10 Years to 18 Years. Per ClinicalTrials.gov, last updated 2023-09-06.
Sponsored by Faculdade de Ciências Médicas da Santa Casa de São Paulo · Not applicable, Interventional, and Treatment
Inflammatory markers have been analyzed in several diseases of unknown etiology, in the expectation of increasing therapeutic perspectives. This possibility arises from the different levels of tissue injury with low-grade chronic inflammation that have been observed in studies in which the markers were not evaluated traditionally, and today have influenced clinical management.
The investigators aimed, therefore, to evaluate the inflammatory markers in patients with AIS before and after aerobic and combined exercise training.
Inflammatory markers have not been evaluated in adolescent idiopathic scoliosis (AIS), but this deformity potentially involves various musculoskeletal structures permanently, which justifies the analysis. A low-grade chronic inflammation may be related to the lower capacity in exercise performance observed in this population, which must be stimulated to perform standardized physical activity.
603 studies on the registry are indexed under Scoliosis; 141 are open to participants now.
This study's enrollment of 40 is close to the median of 44 across 350 interventional studies indexed under Scoliosis.
Browse Scoliosis studies →Faculdade de Ciências Médicas da Santa Casa de São Paulo is the lead sponsor of 41 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
\- 10 minutes of warming, aerobic training 40 minutes on a treadmill (60-80% of maximum heart rate) and resisted training in equipment and free weights for 10 minutes with a set of 10 repetitions in quadriceps, triceps and biceps of the arms and legs (36 sessions)
Other: combined exercise · Device: treadmill
10 minutes of warming, aerobic training 40 minutes on a treadmill (60-80% of maximum heart rate) for 36 sessions
Other: aerobic exercise · Device: treadmill
aerobic training 40 minutes on a treadmill (60-80% of maximum heart rate)
aerobic training 40 minutes on a treadmill (60-80% of maximum heart rate); resisted training in equipment and free weights for 10 minutes with a set of 10 repetitions in quadriceps, triceps and biceps of the arms and legs
interleukin 1
Inflammatory Markers
Time frame: change from baseline in interleukin 1 at 3 months
interleukin 6
Inflammatory Markers
Time frame: change from baseline in interleukin 6 at 3 months
interleukin 8
Inflammatory Markers
Time frame: change from baseline in interleukin 8 at 3 months
distance in six-minute walk test
analysis of distance
Time frame: change from baseline in distance at 3 months
oxygen saturation in six-minute walk test
analysis of oxygen saturation at end of test
Time frame: change from baseline in oxygen saturation at 3 months
systolic blood pressure in six-minute walk test
analysis of systolic blood pressure at end of test
Time frame: change from baseline in systolic blood pressure at 3 months
diastolic blood pressure in six-minute walk test
analysis of diastolic blood pressure at end of test
Time frame: change from baseline in diastolic blood pressure at 3 months
heart rate in six-minute walk test
analysis of heart rate at end of test
Time frame: change from baseline in heart rate at 3 months
respiratory frequency in six-minute walk test
analysis of respiratory frequency at end of test
Time frame: change from baseline in respiratory frequency at 3 months
Borg scale in six-minute walk test
analysis of Borg scale at end of test
Time frame: change from baseline in Borg scale at 3 months
forced vital capacity (FVC)
analyzed in liters or % of predicted of lung capacity variation from baseline at 3 months
Time frame: change from baseline at 3 months
maximal inspiratory pressure (MIP)
analysis of maximal inspiratory pressure variation (cmH2O)
Time frame: change from baseline at 3 months
maximal expiratory pressure (MEP)
analysis of maximal expiratory pressure variation (cmH2O)
Time frame: change from baseline at 3 months
peak expiratory flow
peak expiratory flow variation analysis in liters / minute (l/min)
Time frame: change from baseline at 3 months
forced expiratory volume in the first second (FEV1)
analyzed in liters or % of predicted of lung volume variation from baseline at 3 months
Time frame: change from baseline at 3 months
forced expiratory volume in the first second (FEV1) / forced vital capacity (FVC)
Analysis (%) of the relationship between FEV1 and FVC with variation from baseline at 3 months
Time frame: change from baseline at 3 months
FORCED EXPIRATORY FRACTION (FEF25-75%)
analyzed in milliliters (ml) of lung volume variation from baseline at 3 months
Time frame: change from baseline at 3 months
FORCED EXPIRATORY FRACTION (FEF25-75%) / forced vital capacity (FVC)
Analysis (%) of the relationship between FEV1 and FVC with variation from baseline at 3 months
Time frame: change from baseline at 3 months
This study is completed, as verified in Nov 2019. You cannot join it, but the record below documents what was studied.
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Faculdade de Ciências Médicas da Santa Casa de São Paulo