An interventional study of stress in Childhood Trauma and Major Depressive Disorder, sponsored by Charite University, Berlin, Germany. Completed at 1 site in Germany. Open to female participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-03-07.
Sponsored by Charite University, Berlin, Germany · Not applicable, Interventional, and Basic science
This study evaluates the association between early trauma, depression and metabolic symptoms.
Early traumatic stress is associated with alterations of the hypothalamic-pituitary-adrenal axis (HPA-axis) indicated by an increased response to stress, a diminished negative feedback and alterations in expression of glucocorticoid receptors. Patients with a history of childhood trauma are more likely to develop metabolic disorders such as diabetes mellitus type 2 or metabolic syndrome.
The investigators will examine participants with and without early life stress and with and without major depression. The investigators assume that traumatized study participants (1) show an increased endocrine stress reaction to psychosocial stress, (2) display an altered sensitivity of GR, and (3) therefore suffer from an adverse cardiovascular risk profile in comparison to not-traumatized participants.
The investigators study will increase current knowledge on possible sequel of early traumatic stress. The results will lead to a more comprehensive understanding of stress-related eating behaviour and its implications.
4,845 studies on the registry are indexed under Depressive Disorder; 514 are open to participants now.
This study's enrollment of 140 is above the median of 80 across 3,999 interventional studies indexed under Depressive Disorder.
Browse Depressive Disorder studies →Charite University, Berlin, Germany is the lead sponsor of 836 studies on the registry; 129 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
stress
Other: stress
stress
Other: stress
stress
Other: stress
stress
Other: stress
Endocrine response to stress (salivary cortisol)
salivary cortisol
Time frame: 2 hours
glucose to oral glucose tolerance test (plasma insulin)
plasma glucose
Time frame: 2 hours
insulin to oral glucose tolerance test (plasma insulin)
plasma insulin
Time frame: 2 hours
cortisol to corticotropin releasing factor (salivary cortisol)
salivary cortisol
Time frame: 3 hours
This study is completed, as verified in Mar 2016. You cannot join it, but the record below documents what was studied.
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Charite University, Berlin, Germany