An interventional study of High Resolution Computed Tomography scan in Bronchiolitis Obliterans and Lung Transplant Rejection, sponsored by FLUIDDA nv. Completed at 2 sites in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-03-29.
Sponsored by FLUIDDA nv · Not applicable, Interventional, and Diagnostic
The objective of this study is to detect Bronchiolitis Obliterans Syndrome (BOS) in an early stage using the outcome parameters generated by Functional Respiratory Imaging (FRI). Robust and automated segmentation algorithms will be developed for these parameters, focusing on quantitative computed tomography (CT) image analyses to provide the physician a more sensitive diagnostics tool. The evolution of BOS over time will be monitored using non-rigid image registration methods.
360 studies on the registry are indexed under Bronchiolitis; 43 are open to participants now.
This study's enrollment of 8 is below the median of 80 across 249 interventional studies indexed under Bronchiolitis.
Browse Bronchiolitis studies →FLUIDDA nv is the lead sponsor of 13 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
HRCT scan will be taken
Radiation: High Resolution Computed Tomography scan
a HRCT scan at Functional Residual Capacity (FRC) and Total Lung Capacity (TLC) will be taken on visit 1, visit 2, visit 3, visit 4 and visit 5. An Upper Airway (UA) scan will be taken on visit 1.
Also known as: HRCT scan
Airway Volume (iVaw)
Exploratory imaging endpoints: HRCT-scan will be taken at visit 1 - visit 5.
Time frame: 12 months
Airway Resistance (iRaw)
Exploratory imaging endpoints: HRCT-scan will be taken at visit 1 - visit 5.
Time frame: 12 months
Specific Airway Volume (siVaw)
Exploratory imaging endpoints: HRCT-scan will be taken at visit 1 - visit 5.
Time frame: 12 months
Specific Airway Resistance (siRaw)
Exploratory imaging endpoints: HRCT-scan will be taken at visit 1 - visit 5.
Time frame: 12 months
Lobe volumes (iVlobes)
Exploratory imaging endpoints: HRCT-scan will be taken at visit 1 - visit 5.
Time frame: 12 months
Air trapping
Exploratory imaging endpoints: HRCT-scan will be taken at visit 1 - visit 5.
Time frame: 12 months
Internal Lobar Airflow Distribution
Exploratory imaging endpoints: HRCT-scan will be taken at visit 1 - visit 5.
Time frame: 12 months
Low Attenuation or Emphysema Score
Exploratory imaging endpoints: HRCT-scan will be taken at visit 1 - visit 5.
Time frame: 12 months
Blood Vessel Density or Fibrosis Score
Exploratory imaging endpoints: HRCT-scan will be taken at visit 1 - visit 5.
Time frame: 12 months
Airway Wall Thickness
Exploratory imaging endpoints: HRCT-scan will be taken at visit 1 - visit 5.
Time frame: 12 months
This study is completed, as verified in Feb 2016. You cannot join it, but the record below documents what was studied.
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FLUIDDA nv