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Status unknownNCT02352727PDUpdated Feb 2, 2015

The Measurement of Nocturnal Hypokinesia in Parkinson's Disease (PD) Patient Compared With Spouse by Wearable Sensors

An observational study in Parkinson Disease, sponsored by Chulalongkorn University. Status unknown at 1 site in Thailand. Per ClinicalTrials.gov, last updated 2015-02-02.

Sponsored by Chulalongkorn University · Observational

The sponsor has not verified this record recently (last verified Jan 2015), so the status shown — last known as Enrolling by invitation — may be out of date.
Study type
Observational
Model
Case-control
Time perspective
Cross-sectional
Enrollment
28
Sex
All
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Study summary

To quantitative measurement of nocturnal hypokinesia of Parkinson's disease patients compares with their spouses by using multisite accelerometers for 1 night at their home. To determine whether the nocturnal movement of Parkinson's disease patients less than normal elderly people or not.

Read the detailed description

To quantify the severity of nocturnal akinesia, the nocturnal akinesia dystonia and cramp score (NADCS) and Unified Parkinson's Disease Rating Scale (UPDRS) were recorded in the patient group and also details of demographic data, history and physical examinations were included. The patients and spouses wore the 3-axis (x,y,z) accelerometers at bilateral wrists, bilateral ankles, and trunk for 1 night at their home. The 5-minute periods after going to bed and before waking up in the morning were excluded from the analysis. The definition of movement of the trunk is a change of 15 degrees from the previous position and sustained for 5 minutes in any axis. The movement of limbs is defined as a change of 15 degrees from the previous position and sustained for 2 minutes.

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Conditions studied

  • Parkinson Disease

Keywords

  • Nocturnal hypokinesia
  • Accelerometers
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In context

Parkinson Disease

4,487 studies on the registry are indexed under Parkinson Disease; 1,082 are open to participants now.

This study's planned enrollment of 28 is below the median of 96 across 1,057 observational studies indexed under Parkinson Disease.

Browse Parkinson Disease studies →

Lead sponsor

Chulalongkorn University is the lead sponsor of 312 studies on the registry; 59 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

we study the Parkinson's disease patients and their spouses who received the treatment at King Chulalongkorn Memorial Hospital.

Inclusion criteria

  • Parkinson's disease patients who met the criteria diagnosis of United Kingdom Parkinson's Disease Society Brain Bank (UKPDSBB) with their spouses which age difference less than 10 years.

Exclusion criteria

Exclusion Criteria:

    1. patients and/or spouses who were bed ridden,
    1. a history of other neurological diseases or other muscle and joint diseases,
    1. no history of hypnotic drug use
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Study design

Observational model
Case-control
Time perspective
Cross-sectional
Enrollment
28 participants (estimated)
Patient registry
No
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What researchers measure

Primary outcomes

  1. the number of axial movement of Parkinson's disease patients compare to their spouses defined by accelerometer

    Time frame: one year

  2. the velocity of axial movement of Parkinson's disease patients compare to their spouses defined by accelerometer

    Time frame: one year

  3. the acceleration of axial movement of Parkinson's disease patients compare to their spouses by accelerometer

    Time frame: one year

Secondary outcomes

  1. The correlations between nocturnal hypokinesia parameter (number of axial movement) and severity of Parkinson's disease.

    The correlation between number of axial movement and UPDRS.

    Time frame: one year

  2. The correlations between nocturnal hypokinesia parameter (velocity of axial movement) and severity of Parkinson's disease.

    The correlation between velocity of axial movement and UPDRS.

    Time frame: one year

  3. The correlations between nocturnal hypokinesia parameter (degree of axial movement) and severity of Parkinson's disease.

    The correlation between degree of axial movement and UPDRS.

    Time frame: one year

Other outcomes

  1. The number of nocturia of Parkinson's disease patient

    Time frame: one year

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Study locations

1 site
  • Faculty of Medicine
    Bangkok, 10330, Thailand
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References and documents

Publications

  • Stack EL, Ashburn AM. Impaired bed mobility and disordered sleep in Parkinson's disease. Mov Disord. 2006 Sep;21(9):1340-2. doi: 10.1002/mds.20944. PubMed 16773640 ↗
  • Chaudhuri KR, Schapira AH. Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment. Lancet Neurol. 2009 May;8(5):464-74. doi: 10.1016/S1474-4422(09)70068-7. PubMed 19375664 ↗
  • Verbaan D, van Rooden SM, Visser M, Marinus J, van Hilten JJ. Nighttime sleep problems and daytime sleepiness in Parkinson's disease. Mov Disord. 2008 Jan;23(1):35-41. doi: 10.1002/mds.21727. PubMed 17960797 ↗
  • Steiger MJ, Thompson PD, Marsden CD. Disordered axial movement in Parkinson's disease. J Neurol Neurosurg Psychiatry. 1996 Dec;61(6):645-8. doi: 10.1136/jnnp.61.6.645. PubMed 8971118 ↗
  • Bhidayasiri R, Mekawichai P, Jitkritsadakul O, Panyakaew P, Kaewwilai L, Boonrod N, Petchrutchatachart S, Jagota P, Boonpeng K, Singmaneesakulchai S, Setthawatcharawanich S. Nocturnal journey of body and mind in Parkinson's disease: the manifestations, risk factors and their relationship to daytime symptoms. Evidence from the NIGHT-PD study. J Neural Transm (Vienna). 2014 Aug;121 Suppl 1:S59-68. doi: 10.1007/s00702-014-1199-x. Epub 2014 Mar 31. PubMed 24682359 ↗
  • Salarian A, Russmann H, Vingerhoets FJ, Burkhard PR, Aminian K. Ambulatory monitoring of physical activities in patients with Parkinson's disease. IEEE Trans Biomed Eng. 2007 Dec;54(12):2296-9. doi: 10.1109/tbme.2007.896591. PubMed 18075046 ↗
  • Yang CC, Hsu YL. A review of accelerometry-based wearable motion detectors for physical activity monitoring. Sensors (Basel). 2010;10(8):7772-88. doi: 10.3390/s100807772. Epub 2010 Aug 20. PubMed 22163626 ↗
  • Maetzler W, Domingos J, Srulijes K, Ferreira JJ, Bloem BR. Quantitative wearable sensors for objective assessment of Parkinson's disease. Mov Disord. 2013 Oct;28(12):1628-37. doi: 10.1002/mds.25628. Epub 2013 Sep 12. PubMed 24030855 ↗
  • Weller C, Nicholson PW, Dobbs SM, Bowes SG, Purkiss A, Dobbs RJ. Reduced axial rotation in the spouses of sufferers from clinical idiopathic parkinsonism. Age Ageing. 1992 May;21(3):189-94. doi: 10.1093/ageing/21.3.189. PubMed 1615781 ↗
  • Weller C, Bowes SG, Kirk CA, Nicholson PW, Dobbs RJ, Dobbs SM. Measurement of axial rotation: its relevance to screening for night-time hypokinesia in old age and parkinsonism. Age Ageing. 1991 Jan;20(1):3-7. doi: 10.1093/ageing/20.1.3. PubMed 2028848 ↗
  • Godfrey A, Conway R, Meagher D, OLaighin G. Direct measurement of human movement by accelerometry. Med Eng Phys. 2008 Dec;30(10):1364-86. doi: 10.1016/j.medengphy.2008.09.005. Epub 2008 Nov 8. PubMed 18996729 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 2, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02352727
Lead sponsor
Chulalongkorn University
Responsible party
Jirada Sringean (Dr, Chulalongkorn University) — Principal investigator
First posted
Feb 2, 2015
Start date
May 2014
Primary completion
Jan 2016 (estimated)
Last update
Feb 2, 2015
View the source record on ClinicalTrials.gov ↗

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This study is status unknown, as verified in Jan 2015. You cannot join it, but the record below documents what was studied.

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