An interventional study of Isometric handgrip training in Hypertension, sponsored by University of Pernambuco. Completed at 1 site in Brazil. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-10-04.
Sponsored by University of Pernambuco · Not applicable, Interventional, and Treatment
The main purpose this study is to analyze the effects of isometric handgrip training on cardiovascular risk in hypertensive. For this, approximately 60 hypertensive, under anti-hypertensive medication, will be selected and randomly distributed into three groups: home-based isometric handgrip training (HBT), supervised isometric handgrip training (ST) and control group (CG).Subjects assigned to the HBT and ST will train three times per week for a total of 12 weeks, will perform a bout of isometric handgrip exercise: four sets of 2-min isometric contractions (using alternate hands) at 30% of maximal voluntary contraction. However, the subjects of the HBT group conduct the training without daily supervision. Subjects randomized to the CG will be encouraged to increase the level of physical activity and make healthy eating, without, however, receive specific recommendations.Baseline and after 12 weeks of intervention, the following cardiovascular risk indicators will be obtained: blood pressure, arterial stiffness, cardiac autonomic modulation, vasodilatory capacity and oxidative and inflammatory stress markers, in addition to microalbuminuria. For data analysis, in addition to descriptive statistics, two-way ANOVA for mixed model will be applied for within and between groups comparison. If the premises of this test are met. The level of significance that will be adopted is p\<0.05.
6,689 studies on the registry are indexed under Hypertension; 965 are open to participants now.
This study's enrollment of 72 is below the median of 90 across 4,995 interventional studies indexed under Hypertension.
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Exclusion Criteria:
All participants that will be assigned to home-based isometric handgrip training (HBT) will train three times per week for a total of 12 weeks, will perform a bout of isometric handgrip exercise: four sets of 2-min isometric contractions (using alternate hands) at 30% of maximal voluntary contraction; however, the training will be performed without daily supervision. Therefore, the subjects will receive a logbook to record the exercise sessions. In addition, visits will be scheduled at weeks 1, 3, 6, 9 and 11 to provide feedback to individuals and discuss potential problems in conducting training.
Other: Isometric handgrip training
All participants that will be assigned to supervised isometric handgrip training (ST) will train three times per week for a total of 12 weeks, will perform a bout of isometric handgrip exercise: four sets of 2-min isometric contractions (using alternate hands) at 30% of maximal voluntary contraction with. The training will be performed with daily supervision.
Other: Isometric handgrip training
Subjects randomized to the control group (CG) will be encouraged to increase the level of physical activity and make healthy eating, without, however, receive specific recommendations
The two experimental groups (HBT and ST) will receive intervention with isometric handgrip exercise for 12 weeks, and the HBT group without daily supervision.
Also known as: Exercise
Change in office blood pressure
Time frame: Baseline and 12 weeks
Change in ambulatory blood pressure
Time frame: Basaline and 12 weeks
Change in central blood pressure
Time frame: Basaline and 12 weeks
Change in cardiac autonomic modulation
Time frame: Baseline and 12 weeks
Change in vasodilatory capacity
Time frame: Baseline and 12 weeks
Change in arterial stiffness
Time frame: Baseline and 12 weeks
Change in markers of oxidative stress
Time frame: Baseline and 12 weeks
Change in markers of inflammation
Time frame: Baseline and 12 weeks
Adherence to training
Adherence to training will be evaluated by the number of subjects who completed the two types of training
Time frame: 12 weeks
Change in handgrip strength
Time frame: Baseline and 12 weeks
This study is completed, as verified in Oct 2017. You cannot join it, but the record below documents what was studied.
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University of Pernambuco